Modeling COPD and asthma in a human small airway-on-a-chip
2015年12月21日 · A multi-component microfluidic small airway-on-a-chip model provides new opportunities to study human lung inflammatory disorders such as chronic obstructive pulmonary disease (COPD) and asthma, and to test preclinical drug candidates outside the human body.
In vitro human cell-based models to study airway remodeling in asthma …
2023年3月1日 · Precision cut lung slices (PCLS) have gained increasing interest in asthma research. To generate PCLS, the lung from donors is usually instilled with warm liquid agarose via tracheal, and then immersed in the ice-cold buffer to solidify the agarose.
Lung Remodeling in a Mouse Model of Asthma Involves a …
In the present study, we first established a model of chronic asthma where OVA-immunized mice were given six OVA challenges, and measured collagen deposition around bronchi and α-SMA as markers of fibrosis. These parameters, as well as mucus secretion, were significantly increased in the asthma model.
Computational modeling of the obstructive lung diseases asthma …
We discuss application of modeling techniques to obstructive lung diseases, namely asthma and emphysema and the use of models to predict response to therapy. Finally we introduce a large European project, AirPROM that is developing multiscale models to investigate structure-function relationships in asthma and COPD. ... Uhlig S, Wall WA ...
Airway inflammation in a novel mouse model of asthma-COPD …
2024年5月21日 · In this study, we exposed papain-induced asthma model mice to tobacco smoke to establish an ACO mouse model, in which features of airway inflammation observed in both asthma and COPD were incorporated.
Animal Models of Asthma - Charles River Laboratories
Leverage our expertise with a wide array of well-characterized in vivo models, a variety of administration routes (including inhalation), and clinically relevant endpoints to tailor your respiratory discovery projects.
A human model of asthma exacerbation reveals transcriptional
2023年5月5日 · Using a human model of allergen-induced asthma exacerbation, we compared the lower airway mucosa in allergic asthmatics and allergic non-asthmatic controls using single-cell RNA sequencing.
Modeling COPD, asthma in a human small airway-on-a-chip
2015年12月21日 · A research team has leveraged its organ-on-a-chip technology to develop a model of the human small airway in which lung inflammatory diseases, such as chronic obstructive pulmonary disease...
Lung Computational Models and the Role of the Small Airways in Asthma
2019年10月10日 · Using computer models of the lungs, we show that R5 − R20 was found to be an anatomically sensitive measure of small airway disease. The models predicted that small airway narrowing would have a significant impact on both asthma control and quality of life, and that narrowing could, in part, be reversed by antiinflammatory biologics.
Modelling airway remodelling in asthma - ScienceDirect
2004年12月1日 · Airway remodelling is increasingly recognised to be a serious consequence of chronic asthma. Although the acute inflammation associated with asthma has been modelled extensively both in vitro and in vivo, the structural changes occurring in the lung have only recently been investigated.