ASH1L (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. …

2024年12月24日 · ASH1L (ASH1 Like Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with ASH1L include Intellectual Developmental Disorder, …

The ASH1L gene, also known as KMT2H , provides instructions for making an enzyme, called lysine-specific methyltransferase 2H, that is found in many organs and tissues of the body. …

ASH1L-related syndrome happens when there are changes to the ASH1L gene. These changes can keep the gene from working as it should. The ASH1L gene plays a key role in brain …

2022年4月6日 · We find haploinsufficiency of Ash1l causally induces anxiety and autistic-like behavior, including repetitive behavior, and alters social behavior. Specific depletion of Ash1l …

2021年5月14日 · ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive drug …

Our studies are the first to provide a basic mechanistic insight into epigenetic interactions wherein placement, interpretation, and removal of H3K36me2 contribute to the regulation of gene …

Here we report that ASH1L is an HMTase that associates with all active genes examined. Association of ASH1L with active genes occurs irrespective of cell type. ASH1L is found at …

2025年2月9日 · Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta …

The ASH1L gene encodes a histone methyltransferase involved in epigenetic modification of chromatin. It associates with the transcribed region of genes important in development, …