Aug 3, 2022 · Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used ...

文章揭示了asgr1在胆固醇排泄代谢中的关键作用，通过一种涉及 lxr稳定 而无需脂质生成激活的机制促进胆固醇排泄，并通过小鼠模型的验证，证实了asgr1中和抗体和小核酸药物在临床前阶段的有效性。

asgr1 是唾液酸糖蛋白受体的主要亚型，在肝脏中特异表达，介导血液 去唾液酸糖蛋白 的内吞并转运至溶酶体降解。在一项针对冰岛人的大规模基因研究中发现，功能缺失的asgr1变异与低胆固醇和cvd风险降低有关。

Mar 8, 2024 · Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male mice with liver...

Dec 24, 2024 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B . Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification .

Jan 23, 2023 · In a recent study, Wang et al. 1 discovered that inhibition of asialoglycoprotein receptor 1 (ASGR1) (a GWAS identified gene associated coronary artery disease) could upregulate ABCG5, ABCG8, and...

The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. ^ "Human PubMed Reference:".

Nov 1, 2024 · ASGR1 (asialoglycoprotein receptor 1), predominantly expressed on hepatocytes, has emerged as a key regulator of cholesterol metabolism and low-density lipoprotein (LDL) clearance.

Jan 23, 2023 · ASGR1: an emerging therapeutic target in hypercholesterolemia Signal Transduct Target Ther. 2023 Jan 23;8(1):43. doi: 10.1038/s41392-023-01319-5. Authors Wenqi Zhao 1 , Suowen Xu 2 , Jianping Weng 3 Affiliations 1 Department of Endocrinology, Institute of Endocrine and Metabolic ...

Nov 30, 2024 · In this study, we investigated the impact of ASGR1 deficiency (ASGR1 −/−) on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N -glycome under the hypercholesterolemic condition in ApoE-deficient mice.