
Inhibition of ASGR1 decreases lipid levels by promoting ... - Nature
2022年8月3日 · Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used...
Asialoglycoprotein receptor 1 - Wikipedia
Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene. [5] This gene encodes a subunit of the asialoglycoprotein receptor.
ASGR1 Gene - GeneCards | ASGR1 Protein | ASGR1 Antibody
2024年12月24日 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification.
Deficiency of ASGR1 promotes liver injury by increasing GP73
2024年3月8日 · Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male mice with liver...
ASGR1: an emerging therapeutic target in hypercholesterolemia
2023年1月23日 · ASGR1 is a receptor localized on the surface of hepatocytes, which renders it possible to perform structure-based drug discovery to identify ligand analogs or small-molecule compounds that can ...
Inhibition of ASGR1 decreases lipid levels by promoting ... - PubMed
Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used hypocholesterolaemic drugs.
ASGR1 deficiency improves atherosclerosis but alters liver …
2024年11月30日 · In this study, we investigated the impact of ASGR1 deficiency (ASGR1 −/−) on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N -glycome under the hypercholesterolemic condition in ApoE-deficient mice.
Genetically mimicked effects of ASGR1 inhibitors on all-cause …
2023年7月3日 · Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, we investigated genetically mimicked ASGR1 inhibitors on all-cause mortality and any possible adverse effects.
ASGR1 and ASGR2, the Genes that Encode the Asialoglycoprotein …
Background. The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. …
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1 …
2021年10月8日 · A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non–HDL-cholesterol (non–HDL-c) levels and reduced risks of cardiovascular diseases. However, the mechanism behind this phenomenon remained unclear.