2022年8月3日 · Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used...

Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene. [5] This gene encodes a subunit of the asialoglycoprotein receptor.

2024年12月24日 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification.

2024年3月8日 · Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male mice with liver...

2023年1月23日 · ASGR1 is a receptor localized on the surface of hepatocytes, which renders it possible to perform structure-based drug discovery to identify ligand analogs or small-molecule compounds that can ...

Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used hypocholesterolaemic drugs.

2024年11月30日 · In this study, we investigated the impact of ASGR1 deficiency (ASGR1 −/−) on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N -glycome under the hypercholesterolemic condition in ApoE-deficient mice.

2023年7月3日 · Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, we investigated genetically mimicked ASGR1 inhibitors on all-cause mortality and any possible adverse effects.

Background. The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. …

2021年10月8日 · A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non–HDL-cholesterol (non–HDL-c) levels and reduced risks of cardiovascular diseases. However, the mechanism behind this phenomenon remained unclear.