Inhibition of ASGR1 decreases lipid levels by promoting ... - Nature
2022年8月3日 · Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely …
Asialoglycoprotein receptor 1 - Wikipedia
Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene. [5] This gene encodes a subunit of the asialoglycoprotein receptor.
ASGR1 Gene - GeneCards | ASGR1 Protein | ASGR1 Antibody
2024年12月24日 · ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include Hepatitis and Hepatitis B. Among its related pathways are …
Deficiency of ASGR1 promotes liver injury by increasing GP73
2024年3月8日 · Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male …
ASGR1: an emerging therapeutic target in hypercholesterolemia
2023年1月23日 · ASGR1 is a receptor localized on the surface of hepatocytes, which renders it possible to perform structure-based drug discovery to identify ligand analogs or small …
Inhibition of ASGR1 decreases lipid levels by promoting ... - PubMed
Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic beneficial effects with atorvastatin or ezetimibe, two widely used …
ASGR1 deficiency improves atherosclerosis but alters liver …
2024年11月30日 · In this study, we investigated the impact of ASGR1 deficiency (ASGR1 −/−) on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating …
Genetically mimicked effects of ASGR1 inhibitors on all-cause …
2023年7月3日 · Asialoglycoprotein receptor 1 (ASGR1) is emerging as a potential drug target to reduce low-density lipoprotein (LDL)-cholesterol and coronary artery disease (CAD) risk. Here, …
ASGR1 and ASGR2, the Genes that Encode the Asialoglycoprotein …
Background. The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The …
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1 …
2021年10月8日 · A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non–HDL-cholesterol (non–HDL-c) levels …