(+)-artemisinin is a sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial and a plant metabolite.

Artemisinin is an antimalarial lactone derived from qinghao (青蒿, Artemisia annua or sweet wormwood). In 1596, Li Shizhen recommended tea made from qinghao specifically to treat malaria symptoms in his Compendium of Materia Medica.

Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis.

2012年8月27日 · After screening of over 5000 traditional Chinese medicines, Qinghaosu (QHS), an antimalarial principle, was isolated from Artemisia annua L in 1972 1, 2. At the end of 1975, its unique chemical...

Artemisinin (qinghaosu) has a unique structure bearing a stable endoperoxide lactone (1,2,13-trioxane) totally different from previous antimalarial in its structure and mode of...

2019年2月1日 · Artemisinin (and its various derivatives, which we will refer to collectively as “artemisinin” unless otherwise specified) is a sesquiterpene lactone compound (Fig. 1) with a unique chemical structure derived from the sweet wormwood plant, Artemisia annua L. (Fig. 2).

The unusual tetracyclic structure of 1 containing a peroxidic 1,2,4-trioxane moiety is known to play an essential role in the antimalarial mechanism of action of artemisinin . Interaction of the endoperoxide moiety with heme, or free Fe (II) leads to the formation of free radical intermediates [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ].