Artemin is a neurotrophic factor in the glial cell line-derived neurotrophic factor family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease.

2021年5月24日 · 神经鞘胚素(Artemin)是胶质细胞源性神经营养因子(GDNF)配体家族的成员，该配体还包括GDNF、Persephin和Neurturin。 GDNF家族配体是TGF-β超家族的远缘成员。 GDNF具有独特的神经营养特性，在神经退行性疾病的基因治疗中具有潜在的应用价值。

2024年12月24日 · ARTN (Artemin) is a Protein Coding gene. Diseases associated with ARTN include Burning Mouth Syndrome and Thyroid Carcinoma, Familial Medullary. Among its related pathways are MAPK family signaling cascades and Nervous system development. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor ...

2002年7月18日 · Artemin (ARTN) is a member of the GDNF family of ligands and signals through the Ret/GFRalpha3 receptor complex. Characterization of ARTN- and GFRalpha3-deficient mice revealed similar abnormalities in the migration and axonal projection pattern of the entire sympathetic nervous system.

2019年2月21日 · Artemin (ARTN) is a neurotrophic factor from the GDNF family ligands (GFLs) that is involved in development of the nervous system and neuronal differentiation and survival. ARTN signals through a complex receptor system consisting of the RET receptor tyrosine kinase and a glycosylphosphatidylinositol-anchored co-receptor GFL receptor α, GFRα3.

GDNF、neuroturin、persephin和artemin是一类结构相似、功能相关的分泌型蛋白质，都具有7个保守的 半胱氨酸 残基，具有相似的空间结构，核苷酸序列、氨基酸顺序也具有较高的同源性。

Artemin is a member of the glial cell line-derived neurotrophic factor family of ligands. 32 It binds to the GFRα3 receptor on the RET receptor tyrosine kinase. 33 This receptor is expressed after axonal damage. 34 Artemin promotes survival of sensory, sympathetic, and central neurons.

Here, we report the identification of Artemin, a novel member of the GDNF family, and demonstrate that it is the ligand for the former orphan receptor GFRalpha3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and its expression pattern suggests that it also influences these neurons in vivo.

Artemin 蛋白是 GFR-alpha-3-RET 和 GFR-alpha-1-RET 受体复合物的配体，对于感觉神经元、交感神经元和多巴胺能神经元的生存至关重要。它强烈吸引肠道造血细胞，促进肠道相关淋巴组织中派尔氏斑块状结构的形成。

2018年1月26日 · Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase.