The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, [1] plays a central role in RNA silencing processes as essential components of the RNA-induced silencing complex (RISC).

Argonaute proteins associate with small non-coding RNAs (such as small interfering (si)RNAs and microRNAs (miRNAs)) and function in RNA-based silencing mechanisms by altering protein synthesis...

Jun 4, 2013 · Argonaute proteins are highly specialized binding modules that accommodate the small RNA component — such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or PIWI-associated RNAs (piRNAs) —...

Jul 1, 2020 · Argonaute proteins play an important role in post-translational gene silencing and the biogenesis of small RNA. Accumulating studies have revealed that Argonaute proteins also implicate several other cellular processes, such as host …

Jan 21, 2020 · Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer.

Jun 21, 2011 · What are Argonaute proteins? Argonaute proteins form an evolutionarily conserved family whose members silence gene expression in pathways such as RNA interference (RNAi). Argonaute family proteins can be divided into AGO and PIWI proteins (Figure 1).

Argonaute RNA is pursuing a number of therapeutic opportunities in RNA interference. RNAi harnesses a cell mechanism that inhibits the expression of a specific gene and thereby inhibits the production of a specific protein. Argonaute RNA research projects build on …

The highly conserved Argonaute protein family members play a central role in the regulation of gene expression networks, orchestrating the establishment and the maintenance of cell identity throughout the entire life cycle, as well as in several ...

Jun 21, 2024 · Argonaute proteins are the central effectors of RNA-guided RNA silencing pathways in eukaryotes, playing crucial roles in gene repression and defense against viruses and transposons.

In plants and animals, at least one member of the conserved ARGONAUTE (AGO) protein family comprises the catalytic engine of the silencing complex, which is guided by sequence-specific small RNA to cognate RNA. In this review, we present general features of plant and animal AGO proteins and detail our knowledge on the 10 Arabidopsis thaliana AGOs.