Argonaute proteins associate with small non-coding RNAs (such as small interfering (si)RNAs and microRNAs (miRNAs)) and function in RNA-based silencing mechanisms by altering protein synthesis...

2000年5月24日 · What is an Argonaut? The word “argonaut” (Ancient Greek: Ἀργοναῦται) comes from an ancient tale sung of the strongest and bravest band of heroes ever assembled in Greek Mythology — Jason and the Argonauts — and literally means “sailors of the Argo.” This myth chronicles Jason’s quest for the Golden Fleece and the restoration of his family’s throne.

2013年6月4日 · Argonaute proteins are highly specialized binding modules that accommodate the small RNA component — such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or PIWI-associated RNAs (piRNAs) —...

2020年7月1日 · Argonaute proteins play an important role in post-translational gene silencing and the biogenesis of small RNA. Accumulating studies have revealed that Argonaute proteins also implicate several other cellular processes, such as host …

2020年1月21日 · Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer.

Argonaut, in Greek legend, any of a band of 50 heroes who went with Jason in the ship Argo to fetch the Golden Fleece. Jason’s uncle Pelias had usurped the throne of Iolcos in Thessaly, which rightfully belonged to Jason’s father, Aeson. Pelias promised to surrender his kingship to Jason if the latter would retrieve the Golden Fleece from Colchis.

2025年1月15日 · Argonaute (Ago) proteins use small nucleic acid guides to identify and regulate complementary DNA or RNA target sequences.

2008年9月2日 · The Argonaute protein family was first identified in plants, and members are defined by the presence of PAZ (Piwi-Argonaute-Zwille) and PIWI domains . Argonaute proteins are highly conserved between species and many organisms encode multiple members of the family (Table 1).

2011年6月21日 · What are Argonaute proteins? Argonaute proteins form an evolutionarily conserved family whose members silence gene expression in pathways such as RNA interference (RNAi). Argonaute family proteins can be divided into AGO and PIWI proteins (Figure 1).

MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional after loading into Argonaute (AGO) proteins to form the effector complexes. Humans ...