2024年12月24日 · AQP7 (Aquaporin 7) is a Protein Coding gene. Diseases associated with AQP7 include Glycerol Quantitative Trait Locus and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Aquaporin-mediated …

最近,水/甘油通道蛋白7 （Aquaglyceroporin 7，AQP7）作为乳腺癌的新的调控靶标被报道[3]，并且AQP7也是癌症患者整体生存率的一个重要预后指标。 据报道，在鼠的乳腺癌模型中， 降低的AQP7表达减少了原发肿瘤的数量和迁移，这样靶定AQP7抑制将为癌症治疗提供新的 ...

2024年12月27日 · Aquaporin-7 (Aqp7) is an aquaglyceroporin that provides transmembrane gateway of water, glycerol, and hydrogen peroxide (H 2 O 2). Analysis of the Gene Expression Omnibus (GEO) database revealed upregulation of hepatic AQP7 expression in liver fibrosis patients. This study aimed to elucidate the role of Aqp7 in the pathogenesis of liver fibrosis.

2023年2月3日 · Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases.

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene. [5] [6] Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily.

2024年9月28日 · Aquaglyceroporin 7 (AQP7), a significant member of the AQP family, is widely distributed throughout the body. For years, AQP7 was predominantly recognized for its role as a small-molecule transporter, facilitating the passage of small molecular substances.

2022年9月1日 · AQP7 maintains cardiovascular homeostasis principally via mediating energy metabolism. Glycerol is an important substance in the basal energy metabolism of the heart. AQP7 acts as a promoter of glycerol metabolism and controls the cardiac glycerol influx/efflux. AQP7 is significantly upregulated in cardiomyocytes of obese mice.

2025年2月8日 · AQP7 is expressed in human and mouse oocytes and upregulated by cryoprotectants. AQP7 is regulated in response to physical training in a gender-dependent manner in adipose tissue. The discovery of an association between urine glycerol loss and a platelet secretion defect is a novel one, and our findings imply the …

2024年12月10日 · Title: AQP7 mediates post-menopausal lipogenesis in adipocytes through FSH-induced transcriptional crosstalk with AP-1 sites. Different expression and localization of aquaporin 7 and aquaporin 9 in granulosa cells, oocytes, and embryos of patients with polycystic ovary syndrome and the negatively correlated relationship with insulin regulation.

关于 aqp7 Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,383,191-33,402,568 (from NCBI) This gene has 19 transcripts (splice variants), 202 orthologues, 11 paralogues and is associated with 1 phenotype.