2021年3月16日 · Certain genes can increase the risk of developing dementia, including Alzheimer’s disease. One of the most significant genetic risk factors is a form of the apolipoprotein E gene called APOE4. About 25% of people carry one copy of APOE4, and 2 …

2024年8月21日 · The APOE gene test identifies the types of the APOE gene in your DNA. The APOE4 gene increases your risk of developing Alzheimer’s disease. The test results aren’t a diagnosis.

2022年5月31日 · Researchers have discovered that a rare mutation inherited with the APOE4 gene variant protects against Alzheimer's, shedding new light on ways to counteract high-risk genes for the disease.

2024年6月7日 · The apolipoprotein E gene (APOE for short) is linked to Alzheimer’s risk because it's involved in the body’s process for carrying cholesterol and other fats in the bloodstream. People can have ...

2024年9月12日 · A rare version of the fibronectin 1 gene may protect against Alzheimer’s in high-risk, APOE ε4 carriers, according to NIA-funded research.

The APOE ε4 genotype combines synergistically with atherosclerosis, peripheral vascular disease, or type 2 diabetes in contributing to an increased risk of AD. 65, 66 APOE ε4 is a risk factor for cardiovascular disease, suggesting that this allele and cerebrovascular disease might have compounding effects on cognitive decline in AD. 67 ...

2024年5月10日 · For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 alleles are not merely at risk, but are destined to develop AD.

2024年5月10日 · Studies have long shown that if you carry two copies of the apolipoprotein E (APOE) 4 gene, your chances of developing Alzheimer’s disease are much higher. Now, researchers say in a new study...

2019年7月31日 · Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk and the APOE* ε 2...

The APOE2 variant is the rarest form of APOE and is associated with a reduced risk for Alzheimer's. The APOE3 variant is the most common and has an average risk for Alzheimer's. The APOE4 variant, present in up to 15% of people, increases the risk for Alzheimer's disease.