Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons .

该基因编码载脂蛋白（apo-）A-II，是高密度脂蛋白颗粒中含量第二高的蛋白质。 该蛋白以单体、同二聚体或异二聚体的形式存在于血浆中，与载脂蛋白D结合。

载脂蛋白C（Apo CⅡ）是CM、VLDL和HDL的结构蛋白之一，分别占其蛋白成份的14%、7%～10%及1%～3%。 Apo CⅡ在血浆中的浓度为0.03-0.05g/L。 人Apo CⅡ为含79个 氨基酸残基 的单链多肽，分子量为9.1kD。 先合成的Apo CⅡ含101氨基酸残，其中 22个氨基酸构成信号肽，除去信号肽后则转变为成熟Apo CⅡ。 Apo CⅡ的等电点为5.0，其氨基酸组成有3个特点: ⑴缺乏组氨酸和 半胱氨酸； ⑵ 含有较多的 极性氨基酸； ⑶苏氨酸及丝氨酸较高。

Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting.

2024年9月18日 · This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells.

Familial apolipoprotein C-II deficiency is a very rare autosomal recessive disorder in which apo C-II is absent, the clearance of chylomicrons from the blood is greatly impaired, and triglycerides accumulate in plasma.

Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting.

该基因编码属于载脂蛋白基因家族的脂质结合蛋白。 该蛋白质在血浆中分泌，是极低密度脂蛋白的组成部分。 这种蛋白质激活脂蛋白脂肪酶，水解甘油三酯，从而为细胞提供游离脂肪酸。 该基因的突变会导致 IB 型高脂蛋白血症，其特征是高甘油三酯血症、黄色瘤以及胰腺炎和早期动脉粥样硬化的风险增加。 该基因与其他相关载脂蛋白基因一起存在于 19 号染色体上的簇中。 该基因与邻近的上游载脂蛋白 C-IV (APOC4) 基因之间存在自然发生的通读转录。 [RefSeq 提供，2011 …

2024年12月24日 · APOC2 (Apolipoprotein C2) is a Protein Coding gene. Diseases associated with APOC2 include Apolipoprotein C-Ii Deficiency and Familial Apolipoprotein C-Ii Deficiency. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Visual phototransduction.

2024年5月8日 · Apolipoprotein CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. It is also found in very low density lipoprotein (VLDL), which is made up of mostly triglycerides (a type of fat in your blood). This article discusses the test used to check for apoCII in a sample of your blood. Alternative Names