2023年7月17日 · Aplastic anemia refers to the syndrome of chronic primary hematopoietic failure from injury leading to diminished or absent hematopoietic precursors in the bone marrow and attendant pancytopenia. Objectives: Identify the etiology and epidemiology of aplastic anemia medical conditions and emergencies.

Idiopathic acquired aplastic anemia (aAA) is a rare, life threatening bone marrow failure syndrome characterized by cytopenias and a hypocellular bone marrow. Aplastic anemia (AA) is classified as either inherited or acquired.

2006年10月15日 · Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Almost universally fatal just a few decades ago, aplastic anemia can now be cured or ameliorated by stem-cell …

Aplastic anemia is an acquired immune-mediated BMF syndrome where marrow disruption is driven by a cytotoxic T cell-mediated autoimmune attack against HSPCs sustained by type I interferons that polarize the immune system toward T helper 1 responses in early phases and then toward T helper 17 and effector memory CD8 + T cell in late stage and ...

2022年1月1日 · In this review, we summarize current knowledge on acquired aplastic anemia pathophysiology. Historically, the term “aplastic anemia” identifies a clinical entity where patients present with anemia and an empty marrow by bone marrow (BM) biopsy [1].

Aplastic anemia (AA) is a life-threatening form of bone marrow failure which, if untreated, is associated with very high mortality. AA refers to pancytopenia in association with bone marrow hypoplasia/aplasia, most often due to immune injury to multipotent hematopoietic stem cells.

The linking of constitutional marrow failure to acquired aplastic anemia through genetic defects in telomere repair has provided the likely explanation for the troubling evolution from an inflammatory pathophysiology, T cell-mediated marrow destruction, to malignant hematologic diseases like myelodysplasia (MDS) and acute myeloid leukemia.

An immune basis for most patients with aplastic anemia (AA) provides a rationale for immunosuppressive therapy (IST), using antithmyocyte globulin and cyclosporine as one therapeutic modality; hematologic response is observed in up to 75% of patients.

What is aplastic anemia? Aplastic anemia is a rare but serious blood disorder. It happens when your bone marrow can’t make enough blood cells and platelets. People with aplastic anemia have an increased risk of serious infections, bleeding issues, heart issues and other complications.

2022年1月1日 · In this review, we summarize current knowledge on acquired aplastic anemia pathophysiology. Historically, the term “aplastic anemia” identifies a clinical entity where patients present with anemia and an empty marrow by bone marrow (BM) biopsy [1].