Apoptotic protease activating factor-1 (Apaf-1) is a key molecule in the intrinsic or mitochondrial pathway of apoptosis, which oligomerizes in response to cytochrome c release and forms a large complex known as apoptosome.

Feb 9, 2025 · Results indicate that the apoptotic protease-activating factor 1 (Apaf-1) apoptosome activates caspase-9 in part through sequestration of the inhibitory caspase recruitment domains (CARDs) domain. Authors found significant up-regulation of miR-221 and significant down-regulation of Apaf-1 expression in LSCC tissues compared to normal nearby ...

Dec 24, 2017 · APAF1 (Apoptotic Peptidase Activating Factor 1) is a Protein Coding gene. Diseases associated with APAF1 include Autism Spectrum Disorder and Transitional Cell Carcinoma. Among its related pathways are TNFR1 Pathway and Apoptosis and survival FAS signaling cascades.

Apr 1, 2017 · Apoptotic protease activating factor-1 (Apaf-1) is a key molecule in the intrinsic or mitochondrial pathway of apoptosis, which oligomerizes in response to cytochrome c release and forms a large complex known as apoptosome.

Apaf1 is the molecular core of the apoptosome, a multiproteic complex mediating the so‐called mitochondrial pathway of cell death. The importance of this pathway during development has been clearly demonstrated by knocking out key genes.

Jan 5, 2025 · Title: APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly. Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis.

In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations.

Feb 2, 2021 · Here we show that mitochondrial permeability transition (MPT) activates caspase-4 by promoting the assembly of a protein complex, which we term the Apaf-1 pyroptosome, for the execution of facilitated pyroptosis.

Feb 1, 2002 · In the case of the latter complex, the central scaffold protein is a mammalian CED-4 homologue known as Apaf-1. This is an ∼130 kDa protein, which in the presence of cytochrome c and dATP oligomerizes to form a very large (∼700–1400 kDa) apoptosome complex.

Feb 4, 2024 · Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis. Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells.