The dimeric transcription factor complex Activator Protein-1 (AP-1) is a group of proteins involved in a wide array of cell processes and a critical regulator of nuclear gene expression during T-cell activation. It is also one of the downstream targets of the MAPK signaling cascade.

AP-1 is another redox-sensitive transcription factor, which regulates cellular proliferation and differentiation during the neoplastic transformation [52]. AP-1 is composed of dimers between the Fos (c-Fos, FosB, Fra-1, and Fra-2) and the Jun (c-Jun, JunB, and JunD) family members.

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their ...

AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site.

AP-1 proteins are a versatile family of dimeric transcription factors. The activator protein-1 (AP-1) proteins are a collection of transcription factors characterized by the presence of a basic leucine zipper (bZip) domain (Fig. 1a).

Here, we focus on the JUN and FOS proteins and aim to offer a new perspective on the molecular mechanisms that regulate the oncogenic and anti-oncogenic effects of AP-1 in tumour development.

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified.

May 1, 2002 · AP-1 proteins as regulators of cell death and survival. Apoptosis suppresses oncogenic transformation, and controls organogenesis and immune responses.

The inflammatory response is known to have a significant role in certain autoimmune diseases and malignancies. We review current knowledge regarding the functions of activator protein 1 (AP-1) as an important modulator in several immune disorders and carcinomas.

Sep 1, 2024 · AP-1 is a DNA-binding protein that contains a basal-leucine zipper (bZIP) domain. Members of the AP-1 family can form homodimers or heterodimers to regulate DNA transcription.