2020 ACC/AHA Heart Valve Disease Guideline: Key Perspectives…
2020年12月17日 · Bioprosthetic SAVR or mitral valve replacement: Anticoagulation with VKA to an INR of 2.5 is reasonable for 3-6 months postoperatively (Class 2b). Mechanical valve prosthesis: The use of direct thrombin inhibitors (dabigatran) or anti-Xa direct oral anticoagulants remains a Class 3 contraindication.
Circulation
2020年12月17日 · Replacement of the aortic valve with a pulmonary autograft (the Ross procedure) is a complex operation involving replacement of the aortic valve by the patient’s own pulmonic valve, along with placement of a pulmonic valve homograft.
Anticoagulation for Valvular Heart Disease - American College …
2015年5月18日 · The ACCP currently recommends VKA therapy with target INR 2.5 (range 2.0 to 3.0) for the first three months after bioprosthetic mitral valve replacement. 12 For aortic valve replacement with a bioprosthetic device, the ACCP recommends aspirin (50 to 100 mg/day) over VKA therapy for the first three months after surgery, for patients in whom ...
Standard Versus Higher Intensity Anticoagulation for Patients …
2021年11月15日 · Current guidelines recommend targeting an international normalized ratio (INR) of 2.5 to 3.5 for patients with mechanical aortic valve replacement (AVR) and additional risk factors for thromboembolic events. Available literature supporting the higher intensity (INR) goal is …
s for Anticoagulation Clinics: Lowered INR 1.5–2.0* for On-X Aortic Heart Valve P. –3.0 for the first 3 months after surgery, after which INR should be reduced to 1.5–2.0. The addition of a daily aspirin at a dose from 75 to 100 mg i. a. ing rates without an increase in TE and stroke rate compared to those with.
Anticoagulation and Antiplatelet Strategies After On-X …
Investigational approaches to reduce the burden of anticoagulation for patients with mechanical heart valves have included targeting a lower international normalized ratio (INR), use of nonwarfarin oral anticoagulants, and dual-antiplatelet therapy (DAPT) for thromboembolic (TE) prophylaxis (4–8).
Optimal Intensity of Warfarin Therapy in Patients With Mechanical ...
The INR goals of 2 to 3 for low risk and 2.5 to 3.5 for high risk should be considered for bileaflet mechanical aortic valve recipients. Additionally, a lower INR goal of 2 to 3 for the first 3 months after valve replacement followed by an INR goal of 1.5 to 2.5 in both low- and high-risk aortic On- …
Current guidelines recommend targeting an international normalized ratio (INR) of 2.5 to 3.5 for patients with mechanical aortic valve replacement (AVR) and additional risk fac-tors for thromboembolic events. Available literature supporting the higher intensity (INR) goal is lacking.
Warfarin in patients with mechanical heart valves | The BMJ
2020年10月15日 · Valve replacement or repair is the definitive treatment in those with severe valvular heart disease.
Antithrombotic Therapy in Patients With Valvular Heart Disease
2021年2月12日 · After valve replacement(s), antithrombotic therapy with an antiplatelet and vitamin K antagonist (VKA) is recommended with the dosing, duration, and international normalized ratio (INR) goal varying among bioprosthetic and …