2024年12月24日 · ANLN (Anillin, Actin Binding Protein) is a Protein Coding gene. Diseases associated with ANLN include Focal Segmental Glomerulosclerosis 8 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle. Gene Ontology (GO) annotations related to this gene include actin binding.

The ANLN gene in humans and the scraps gene in Drosophila encode Anillin. [5] In 1989, anillin was first isolated in embryos of Drosophila melanogaster. It was identified as an F-actin binding protein. [6] Six years later, the anillin gene was cloned from cDNA originating from a …

2025年2月2日 · ANLN enhances initiated Pol II clustering and promotes Pol II CTD phase separation. Short-term depletion of ANLN alters the chromatin binding and enhancer-mediated transcriptional activity of...

2025年2月4日 · 恶性肿瘤的发展基于癌细胞的快速分裂和增殖。Anillin （ANLN） 是一种有丝分裂蛋白，通过调控收缩环组装，促进细胞分裂。该团队于2023年发表了第一篇关于ANLN蛋白异常高表达促进食管鳞癌 （ESCC） 进展的研究 （Cell Death Differ, Cao YF. et al） 。

2025年2月9日 · ANLN promotes carcinogenesis in oral cancer by regulating the PI3K/mTOR signaling pathway. Visualizing dynamic actin cross-linking processes driven by the actin-binding protein anillin. Anillin is an emerging regulator of tumorigenesis, acting as a cortical cytoskeletal scaffold and a nuclear modulator of cancer cell differentiation.

2022年3月17日 · Anillin (ANLN) 是一种普遍表达的肌动蛋白结合蛋白，在细胞生长、迁移和胞质分裂中起着关键的促肿瘤作用。 大量研究表明，ANLN 在许多癌症类型中上调，并且与患者预后和恶性癌症特征显着相关。

2025年2月21日 · ANLN expression was found to negatively correlate with immune score and ESTIMATE scores, while positively correlating with tumor purity. This suggests that higher ANLN expression may reduce immune cell infiltration in the tumor microenvironment, thus potentially impacting the effectiveness of ICB therapy.

2025年2月3日 · Anillin（ANLN）作为一种有丝分裂蛋白，能与 F - 肌动蛋白、肌球蛋白 II 和 RhoA 等细胞骨架元件相互作用，调节细胞分裂，在有丝分裂中组织收缩环组件，推动有丝分裂进程。此前研究发现，ANLN 蛋白丰度对食管鳞状细胞癌（ESCC）细胞分裂和恶性进展至关重要。

关于 anln Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,389,862-36,453,791 (from NCBI) This gene has 13 transcripts (splice variants), 209 orthologues, 2 paralogues and is associated with 2 phenotypes.

2021年8月3日 · Exosomal ANLN-210 promoted macrophage polarization via PTEN/PI3K/Akt signaling pathway, thus stimulating tumor growth of HNSCC. ANLN was an independent prognostic factor in patients with HNSCC.

2025年2月28日 · Anillin (ANLN) is an actin-binding protein responsible for cell motility and muscle cell contraction [6].It functions critically in various cellular processes, especially cytokinesis, growth, and migration [7 – 9].Recent studies revealed that ANLN could serve as the oncogene and participate in tumorigenesis of various cancers, such as oral, colorectal, and breast …

2025年2月2日 · We find that nuclear ANLN directly interacts with the RNA polymerase II (Pol II) large subunit to form transcriptional condensates. ANLN enhances initiated Pol II clustering and promotes Pol II CTD phase separation. Short-term depletion of ANLN alters the chromatin binding and enhancer-mediated transcriptional activity of Pol II.

2020年6月17日 · Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. …

2022年9月20日 · To provide a thorough perspective of ANLN’s roles among diverse malignancies, we conducted a comprehensive, pan-cancer analysis about ANLN, including but not limited to gene expression levels, prognostic value, biological functions, interacting proteins, immune-related analysis, and predictive value.

2024年1月15日 · Using unpaired and paired analyses, we examined ANLN expression in ccRCC tumour and normal samples (Fig. 1 B and C), and found that ANLN expression increased in almost all tumour cell lines, with the highest expression observed in brain lower-grade glioma cell lines (Fig. S1B).

2024年1月15日 · Abnormal anillin (ANLN) expression has been observed in multiple tumours and is closely associated with patient prognosis and clinical features. In this study, we systematically elucidated the clinical significance and biological roles of ANLN in patients with clear cell renal cell carcinoma (ccRCC).

ANLN is a unique scaffolding protein that has been demonstrated to be an important factor in cell division, and it has a close relationship with major cytoskeletal structures. ANLN is usually degraded after mitosis and remains in the nucleus during mitosis.

Anillin (ANLN) is a unique scaffold protein that interacts with cytoskeletal elements such as F-actin, myosin II, and RhoA to regulate cell division 1,2. ANLN promotes mitotic progression by organizing contractile ring components, a process that lasts approximately 40–60 min 3,4.

Anillin actin-binding protein (ANLN) is crucially involved in cell proliferation and migration. Moreover, ANLN is significantly in tumor progression in several types of human malignant tumors; however, it remains unclear whether ANLN acts through ...