- After oral administration, amlodipine is absorbed slowly but extensively from the gastrointestinal tract, with peak plasma concentrations typically occurring between six to twelve hours post-ingest...了解详细信息：After oral administration, amlodipine is absorbed slowly but extensively from the gastrointestinal tract, with peak plasma concentrations typically occurring between six to twelve hours post-ingest...biologyinsights.com/amlodipine-mechanisms-phar…Pharmacokinetics and Metabolism: After oral administration of therapeutic doses of amlodipine besylate tablets, absorption produces peak plasma concentrations between 6 and 12 hours.www.accessdata.fda.gov/drugsatfda_docs/label/20…
Pharmacokinetics and pharmacodynamics of amlodipine
Amlodipine is a low-clearance, dihydropyridine calcium antagonist. The slow rate of elimination (elimination half-life of 40-60 h) confers several pharmacokinetic characteristics that are not seen with other calcium-antagonist drugs. It has high oral bioavailability (60-80%) and accumulates …
- 作者: Darrell R. Abernethy
- Publish Year: 1992
仅显示来自 pubmed.ncbi.nlm.nih.gov 的搜索结果Amlodipine - StatPearls - NC…
With a half-life of 30 to 50 hours, amlodipine affords the convenience of once-daily …
Evaluation of pharmacokineti…
Amlodipine, a main series of L‐type calcium channel blockers (CCBs), exerts potent …
Clinical pharmacokinetics of …
Amlodipine is a dihydropyridine calcium antagonist drug with distinctive …
The metabolism and pharma…
The disposition of amlodipine, a new calcium-channel blocker with a slow …
Amlodipine - StatPearls - NCBI Bookshelf
2024年4月21日 · With a half-life of 30 to 50 hours, amlodipine affords the convenience of once-daily dosing, contrasting with shorter-acting alternatives like nifedipine. Approved as …
- 已发布: 2024/04/21
The pharmacokinetic profile of amlodipine - ScienceDirect
1989年11月1日 · AMLODIPINE PHARMACOKINETICS ine is a dihydropyridine calcium antagonist that was synthesized in an attempt to develop a compound with a typical …
- 作者: Darrell R. Abernethy
- Publish Year: 1989
Amlodipine: Mechanisms, Pharmacokinetics, Side Effects, and ...
2024年10月7日 · Pharmacokinetics. When considering the pharmacokinetics of amlodipine, absorption and distribution are crucial elements to understand. After oral administration, …
Clinical pharmacokinetics of amlodipine - PubMed
Amlodipine is a dihydropyridine calcium antagonist drug with distinctive pharmacokinetic characteristics which appear to be attributable to a high degree of ionisation. Following oral …
- 作者: Peter A. Meredith, Henry L. Elliott
- Publish Year: 1992
Evaluation of pharmacokinetics and safety with …
Amlodipine, a main series of L‐type calcium channel blockers (CCBs), exerts potent antihypertensive effects. The aim of this trial was to explore the pharmacokinetics (PK) and safety with bioequivalence of orally administered …
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Pharmacokinetics and Metabolism: After oral administration of therapeutic doses of amlodipine besylate tablets, absorption produces peak plasma concentrations between 6 and 12 hours. …
Clinical Pharmacokinetics of Amlodipine - Springer
2012年11月4日 · Clinical Pharmacokinetics - Amlodipine is a dihydropyridine calcium antagonist drug with distinctive pharmacokinetic characteristics which appear to be attributable to a high degree of ionisation....
The metabolism and pharmacokinetics of amlodipine in humans
The disposition of amlodipine, a new calcium-channel blocker with a slow onset and long duration of action, has been investigated in humans and in the animal species used in the evaluation of …
The pharmacokinetic profile of amlodipine - ScienceDirect
1989年11月1日 · Amlodipine, a dihydropyridine calcium antagonist, was synthesized in an attempt to develop a compound with a pharmacokinetic profile characteristic of this class, which would …
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