α-Bungarotoxin is one of the bungarotoxins, components of the venom of the elapid Taiwanese banded krait snake (Bungarus multicinctus). It is a type of α-neurotoxin , a neurotoxic protein that is known to bind competitively and in a relatively irreversible manner to the nicotinic acetylcholine receptor found at the neuromuscular junction ...

Alpha-bungarotoxin (α-BTX) is a neurotoxin contained in the venom of the Taiwanese many-banded krait. It produces paralysis of striated muscles by blocking cholinergic receptors in the neuromuscular junction. The toxin also blocks a subtype of neuronal cholinergic receptor (α7) located in the central and peripheral nervous systems.

2009年7月1日 · alpha-Bungarotoxin is a peptide toxin produced by the Many-banded krait (Bungarus multicinctus). It is a type of ‘±-neurotoxin, a neurotoxic protein that is known to bind irreversibly and competitively to the acetylcholine receptor found at the neuromuscular junction, causing paralysis, respiratory failure and death in the victim.

α-Bungarotoxin, which is extracted from Bungarus multi cinctus venom, has been used to stain acetylcholine (ACh) recep tors in skel e tal muscle,1 rat myotubules,2 the electric organ from Torpedo californica, 3 and transformed Esche richia coli.4 Mo lec u lar Probes offers unlabeled α-bungarotoxin or α-bungaro toxin labeled with biotin or with...

Alpha-bungarotoxin, a potent toxin produced by the Banded Krait of Taiwan (Bungarus multicinctus), binds to the AChR at multiple sites on the alpha subunit, blocking acetylcholine binding in a manner similar to MG.

Alpha bungarotoxin, isolated from the venom of the Taiwanese many-banded krait Bungarus multicinctus, is a potent antagonist of acetylcholine at the skeletal neuromuscular junction nicotinic acetylcholine receptors (nAChRs), where it produces an irreversible neuromuscular blockade; it also potently blocks neuronal nicotinic α7 nAChRs. The ...

α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC 50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM.

2002年10月12日 · α-Bungarotoxin (Bgtx), a long α-neurotoxin from the venom of the Taiwan banded krait, Bungarus multicinctus, is a high affinity competitive antagonist of muscle-type and certain homo-oligomeric neu...

Bungarotoxins are toxins found in the venom of snakes and kraits. Bites from these animals can result in severe symptoms including bleeding or hemorrhage, paralysis and tissue damage that can result in amputation. The paralytic effects of venom are particularly dangerous as they can impair breathing. [1] .

The nicotinic acetylcholine receptor (nAChR) carries two binding sites for snake venom neurotoxins. α -Bungarotoxin from the Southeast Asian banded krait, Bungarus multicinctus, is a long neurotoxin which competitively blocks the nAChR at the acetylcholine binding sites in a relatively irreversible manner.