ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to …

2024年12月24日 · ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include Asthma and Colorectal Cancer.Among its related pathways …

Recently, it has been suggested that various LOX isoforms should be named according to their encoding genes, such as all 12/15-LOX orthologs from different species should be called as …

2025年2月8日 · ALOX15 single nucleotide polymorphisms (SNPs)have a possible role in focal atherosclerosis plaque formation. These results demonstrate a novel mechanism of …

Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the …

2025年1月16日 · ALOX15 overexpression aggravated the effect of PA, while the knockdown of ALOX15 attenuated PA-induced lipotoxicity. Moreover, the treatment with PPARγ antagonist …

2019年7月3日 · Figure 2 Regulation of ALOX15B and ALOX15 expression in human macrophages. ALOX15B protein is constitutively present in human monocyte-derived …

2025年2月8日 · Title: Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells. Association between arachidonate lipoxygenase 15,c. …

11688 Ensembl ENSG00000179593 ENSMUSG00000020891 UniProt O15296 O35936 RefSeq (mRNA) NM_001141 NM_001039130 NM_001039131 NM_009661 RefSeq (protein) …

ALOX15 plays an important role in the formation of key lipid mediators (e.g., lipoxins and resolvins) to terminate inflammation. ALOX15 expression is downregulated in colon cancer. …

12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Abstract. Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it …

2015年11月15日 · ALOX15 oxygenates the naturally occurring polyenoic fatty acids predominantly at the n-6 position and this reaction requires initial hydrogen abstraction from …

2019年1月1日 · Recently, it has been suggested that various LOX isoforms should be named according to their encoding genes, such as all 12/15-LOX orthologs from different species …

2019年9月23日 · Moreover, concentration of the ALOX15 reaction product 15-hydroxyeicosatetraenoic acid (15-HETE) increased under hypoxia, and addition of an ALOX15 …

2025年1月16日 · Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic disorder worldwide. Arachidonic acid 15-lipoxygenase (ALOX15), an enzyme …

2021年5月27日 · ALOX15 is upregulated during T reg differentiation. To investigate whether T regs expressed ALOX enzymes, we obtained T regs from human CD4 + T-cells and assessed …

ALOX15 (arachidonate 15-lipoxygenase) is involved in homeostatic as well as pathological responses. ALOX15 is responsible for the oxidation of unsaturated fatty acids (at the 15 …

2023年3月6日 · Results ALOX15 bioinformatics analysis showed that ALOX15 decreased significantly in the early stage of LUAD and had no correlation with the survival of lung cancer …

2019年1月1日 · The human reticulocyte type 15-LOX1 (ALOX15) produces predominantly 15(S)-HETE and only little amounts of 12(S)-HETE (ratio of 9:1), while its murine orthologue …