ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products. Gene Function . Kelavkar and Badr (1999) stated that the ALOX15 gene product is implicated in antiinflammation, membrane …

2024年12月24日 · ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include Asthma and Colorectal Cancer.Among its related pathways are Biosynthesis of DPA-derived SPMs and Fatty acid metabolism.Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on single …

Recently, it has been suggested that various LOX isoforms should be named according to their encoding genes, such as all 12/15-LOX orthologs from different species should be called as ALOX15. The purpose of this review is to refresh our understanding on the role of 12/15-LOX (ALOX15) in the pathogenesis of various diseases. Table 1.

2025年2月8日 · ALOX15 single nucleotide polymorphisms (SNPs)have a possible role in focal atherosclerosis plaque formation. These results demonstrate a novel mechanism of parathyroid hormone-induced human bone cell proliferation operating through 12- …

Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) involved in various airway inflammatory diseases.

2025年1月16日 · ALOX15 overexpression aggravated the effect of PA, while the knockdown of ALOX15 attenuated PA-induced lipotoxicity. Moreover, the treatment with PPARγ antagonist GW9662 or CD36 inhibitor sulfosuccinimidyl oleate sodium effectively reduced lipid accumulation and lipotoxicity resulting from ALOX15 overexpression and PA exposure, indicating the ...

2019年7月3日 · Figure 2 Regulation of ALOX15B and ALOX15 expression in human macrophages. ALOX15B protein is constitutively present in human monocyte-derived macrophages and can be further induced by stimulation with bacterial-derived pro-inflammatory stimuli LPS, immune regulatory T-helper type 2 cytokines IL-4 and IL-13, and HIF-1 following …

2025年2月8日 · Title: Identifying ALOX15-initiated lipid peroxidation increases susceptibility to ferroptosis in asthma epithelial cells. Association between arachidonate lipoxygenase 15,c.-292 C > T gene polymorphism and non-cystic fibrosis bronchiectasis in children: a pilot study on the effects on airway lipoxin A4 and disease phenotype.

11688 Ensembl ENSG00000179593 ENSMUSG00000020891 UniProt O15296 O35936 RefSeq (mRNA) NM_001141 NM_001039130 NM_001039131 NM_009661 RefSeq (protein) NP_001034219 NP_001034220 NP_001132 NP_033791 Location (UCSC) Chr 17: 8.04 – 8.05 Mb Chr 11: 69.07 – 69.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse …

ALOX15 plays an important role in the formation of key lipid mediators (e.g., lipoxins and resolvins) to terminate inflammation. ALOX15 expression is downregulated in colon cancer. ALOX15 most likely plays an important regulatory role in suppressing signaling pathways (e.g., NF-κB and STAT3) that promote colitis-associated colonic tumorigenesis.

12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The …

Abstract. Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) involved in various airway inflammatory diseases.

2015年11月15日 · ALOX15 oxygenates the naturally occurring polyenoic fatty acids predominantly at the n-6 position and this reaction requires initial hydrogen abstraction from the n-8 carbon atom. Linoleic acid is converted to 13-HpODE, whereas arachidonic acid is oxidized at C15 forming 15S-HpETE. Interestingly, small amounts (ranging from 3 to 15% of the ...

2019年1月1日 · Recently, it has been suggested that various LOX isoforms should be named according to their encoding genes, such as all 12/15-LOX orthologs from different species should be called as ALOX15. The purpose of this review is to refresh our understanding on the role of 12/15-LOX (ALOX15) in the pathogenesis of various diseases.

2019年9月23日 · Moreover, concentration of the ALOX15 reaction product 15-hydroxyeicosatetraenoic acid (15-HETE) increased under hypoxia, and addition of an ALOX15 inhibitor decreased it. Preconditioned medium from hypoxic human cardiac fibroblast cultures decreased beating frequency of cardiomyocytes derived from human-induced pluripotent stem …

2025年1月16日 · Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic disorder worldwide. Arachidonic acid 15-lipoxygenase (ALOX15), an enzyme catalyzing the peroxidation of polyunsaturated fatty acids, plays a crucial role in various diseases. Here, we sought to investigate the involvement of ALOX15 in MASLD. Results: In this study, …

2021年5月27日 · ALOX15 is upregulated during T reg differentiation. To investigate whether T regs expressed ALOX enzymes, we obtained T regs from human CD4 + T-cells and assessed expression of ALOX5, ALOX12 and ...

ALOX15 (arachidonate 15-lipoxygenase) is involved in homeostatic as well as pathological responses. ALOX15 is responsible for the oxidation of unsaturated fatty acids (at the 15 position) to active hydroperoxy and epoxy metabolites. It is also responsible for the conversion of linoleic acid to anti-tumor 13-S-hydroxyoctadecadienoic acid.ALOX15 is required for IL-4 (interleukin …

2023年3月6日 · Results ALOX15 bioinformatics analysis showed that ALOX15 decreased significantly in the early stage of LUAD and had no correlation with the survival of lung cancer patients. ALOX15 was downregulated in LUAD with low differentiation and metastasis in LUAD. LUAD cell lines showed that the lower the degree of differentiation, the lower the expression of …

2019年1月1日 · The human reticulocyte type 15-LOX1 (ALOX15) produces predominantly 15(S)-HETE and only little amounts of 12(S)-HETE (ratio of 9:1), while its murine orthologue leukocyte-type 12-LOX (encoded by ALOX15 gene), produces small amounts of 15(S)-HETE and primarily 12(S)-HETE (ratio of 1:3). Both these enzymes share 73% amino acid similarity, a ...