ALCAT1 catalyzes remodeling of CL with MLCL and non-linoleic acyl-CoAs like DHA-CoA (C22:6) as substrates, leading to CL peroxidation by ROS and mitochondrial dysfunction.

2024年1月10日 · Acyl-coenzyme A:lyso-cardiolipin acyltransferase-1 (ALCAT1) was confirmed to be involved in the progression of Parkinson’s disease, diet-induced obesity and other ageing-related diseases by regulating pathological cardiolipin remodelling.

Here, we identified acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) as the missing link between hypoxia and CHD in an animal model of myocardial infarction (MI). ALCAT1 is an acyltransferase that promotes mitochondrial dysfunction in aging-related diseases by catalyzing pathological remodeling of cardiolipin.

2012年4月16日 · ALCAT1 Causes Mitochondrial Fragmentation and mtDNA Instability in C2C12 Cells. To investigate a role of ALCAT1 overexpression in regulating mitochondria and ER morphology, we generated C2C12 cell lines stably transfected with flag-tagged ALCAT1 cDNA (C2C12-A1) or vector control (C2C12-V).

2021年12月1日 · ALCAT1 is an acyltransferase that promotes mitochondrial dysfunction in aging-related diseases by catalyzing pathological remodeling of cardiolipin. In support of a causative role of ALCAT1 in CHD, we showed that ALCAT1 expression was potently upregulated by MI, linking myocardial hypoxia to oxidative stress, TLCL depletion, and mitochondrial ...

2021年12月1日 · Here, we identified acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) as the missing link between hypoxia and CHD in an animal model of myocardial infarction (MI). ALCAT1 is an acyltransferase that promotes mitochondrial dysfunction in aging-related diseases by catalyzing pathological remodeling of cardiolipin.

ALCAT1 is a lysocardiolipin acyltransferase that catalyzes pathological cardiolipin remodeling in several aging-related diseases. We show that the onset of diet-induced NAFLD caused autophagic arrest in hepatocytes, leading to oxidative stress, mitochondrial dysfunction, and insulin resistance.

2022年9月1日 · Using mice with transgenic expression of the SOD1G93A as a mouse model of ALS, we investigated a role of ALCAT1 in regulating the onset and development of ALS. We show that upregulated ALCAT1 by the SOD1 G93A protein aggregation is implicated in the pathogenesis of the ALS mice.

2019年3月5日 · Using mice with targeted deletion of ALCAT1, we investigated a role for the enzyme in regulating the onset of MPTP-induced PD. We show that upregulated ALCAT1 expression by MPTP and synucleinopathy, a hallmark of PD, leads to severe oxidative stress, mtDNA mutations, and mitochondrial dysfunction in the brain.

Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) catalyzes acylation of lysocardiolipin back to cardiolipin, an important step in cardiolipin remodeling. The present study reports the catalytic properties of ALCAT1 in vitro and its regulation by ...