As an Operations Officer, you will learn the intricate workings of the accession process, from identifying potential applicants, to shipping Future Soldiers for Initial Active Duty Training (IADT)....

There’s a lot of buzz about the Assignment Interactive Module 2.0 (AIM2) among officers throughout the Army. You may have heard the term thrown around by your S1, your fellow brothers- and...

O AIM2 File Edit View Favorites Tools Help personnel Accountability BAH-PME Coordination HRC Homepage U.S. Army Human Resour.. AIM AIM Portal Access Web Slice Gallery You have been identified as having access to multiple portals within AIM. Please select which portal to access: ASSIGNMENT INTERACTIVE MODULE Unit Management SFAB Management

Research over the past decade has revealed that AIM2 plays essential roles not only in host defense against pathogens but also in inflammatory diseases, autoimmunity, and cancer in inflammasome-dependent as well as -independent manners.

AIM2 is a cytosolic innate immune receptor which recognizes double-stranded DNA (dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of dsDNA leads to the assembly of a large multiprotein oligomeric complex termed the inflammasome.

Absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic dsDNA and induces cytokine maturation, release and pyroptosis. It is composed of AIM2, apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1.

AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin. [7] AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome. [8]

Jan 21, 2009 · Using mouse and human cells, here we identify the PYHIN (pyrin and HIN domain-containing protein) 8 family member absent in melanoma 2 (AIM2) as a receptor for cytosolic DNA, which regulates...

AIM2 is a member of innate immune sensors that detects the presence of DNA, arguably the most conserved molecules in living organisms. However, AIM2 achieves specificity by detecting altered or mislocalized DNA molecules.

AIM2 is a cytoplasmic sensor that recognizes dsDNA of microbial or host origin. Upon binding to DNA, AIM2 assembles a multiprotein complex called the inflammasome, which drives pyroptosis and proteolytic cleavage of the proinflammatory cytokines pro-IL-1β and pro-IL-18.