2024年12月24日 · AIFM2 (AIF Family Member 2) is a Protein Coding gene. Diseases associated with AIFM2 include Ovarian Cancer and Hematologic Cancer. Among its related pathways are Gene expression (Transcription) and Vitamin K metabolism and activation of dependent proteins.

Apoptosis-inducing factor 2 (AIFM2), also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10.

两个研究组同时发现了铁死亡抑制蛋白FSP1（Ferroptosis suppressor protein 1），FSP1最初被鉴定时称为AIFM2（Apoptosis-inducing factor mitochondrial 2) 。AIFM2是由于与凋亡相关的因子AIFM1存在序列相似性而被命名，为了防止混淆，德、美两个研究组决定将该蛋白的名字改为FSP1。FSP1 ...

该基因编码一种结合单链 DNA 的黄素蛋白氧化还原酶，被认为在细菌和病毒 DNA 存在的情况下促进细胞凋亡。 该基因的表达也被发现在结肠癌细胞中由肿瘤抑制蛋白 p53 诱导。 [RefSeq 提供，2010 年 11 月] This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to Apoptosis in the presence of Bacterial and viral DNA.

2020年2月6日 · As a unique BAT-specific first mammalian NDE (external NADH dehydrogenase)-like enzyme, Aifm2 oxidizes NADH to maintain high cytosolic NAD levels in supporting robust glycolysis and to transfer electrons to the electron transport …

2023年9月21日 · AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD +. However, the role of AIFM2 in the progression of human cancers remains largely unexplored. Here, we elucidated the...

2025年2月9日 · AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIF-2 was upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type).

2023年4月21日 · To this end, we demonstrated the importance of the flavoprotein ferroptosis suppressor protein 1 (FSP1), which is encoded by the gene apoptosis-inducing factor mitochondria-associated 2 (AIFM2)....

2019年10月22日 · AIFM2（此后更名为“ ferroptosis-suppressor-protein 1”，简称为FSP1，最初被描述为促凋亡基因），赋予了针对GPX4缺失引起的铁死亡前所未有的保护作用。 研究人员进一步证明，FSP1可以通过泛醌（CoQ 10）抑制铁死亡：其还原形式泛醇捕获介导脂质过氧化作用的脂质过氧自由基，而FSP1通过使用NAD（P）H催化其再生。 FSP1的药理靶向作用与GPX4抑制剂可产生强烈协同作用，从而引发许多癌症个体的铁死亡。 总之，FSP1/CoQ 10 /NAD（P）H作 …

2020年2月6日 · As a unique BAT-specific first mammalian NDE (external NADH dehydrogenase)-like enzyme, Aifm2 oxidizes NADH to maintain high cytosolic NAD levels in supporting robust glycolysis and to transfer electrons to the electron transport …