Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene. [5][6] The AIF1 gene is located within a segment of the major histocompatibility complex class III region.

2024年12月24日 · AIF1 (Allograft Inflammatory Factor 1) is a Protein Coding gene. Diseases associated with AIF1 include Nonarteritic Anterior Ischemic Optic Neuropathy and Traumatic Brain Injury. Among its related pathways are Acute viral myocarditis and Spinal cord injury.

Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has …

2025年2月8日 · Allograft inflammatory factor 1 is a potential diagnostic, immunological, and prognostic biomarker in pan-cancer. Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1.

The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca (2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca (2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1.

Endothelial cell (EC) activation plays a key role in vascular inflammation, thrombosis, and angiogenesis. Allograft inflammatory factor-1 (AIF-1) is a cytoplasmic, calcium-binding, inflammation-responsive scaffold protein that has been implicated in …

Allograft inflammatory factor (AIF)-1 is a cytoplasmic, calcium-binding protein whose expression in transplanted human hearts correlates with rejection and development of coronary artery vasculopathy (CAV).

AIF-1 induces VSMCs to dedifferentiate into macrophage-like cells, enhancing lipid uptake and inflammatory factor secretion through the PKC/NF-κB pathway. Inhibiting AIF-1 could potentially reduce foam cell formation and offer a therapeutic strategy for atherosclerosis.

Allograft Inflammatory Factor-1 (AIF-1) is a 17kDa cytoplasmic, calcium-binding, inflammation-responsive scaffold protein that is mainly expressed in immunocytes. AIF-1 influences the immune system at several key points and thus modulates inflammatory diseases.

2022年3月21日 · AIF-1 (allograft inflammatory factor-1) is a 17 kDa cytosolic protein produced by monocytes, macrophages, and lymphocytes that can be secreted to the outside of the cell and can act as a cytokine [7]. It was initially described for its …