2022年9月13日 · At age <30 years, 9.8% of females and 1.4% of males had elevated NT-proBNP, rising to 76.5% and 81.0%, respectively, at age ≥80 years. After adjusting for risk factors, an NT-proBNP ≥125 pg/mL was more common in females than males (OR, 9.48 [95% CI, 5.60–16.1]).

2023年5月5日 · Over recent years, greater clarity has been gained regarding the understanding of how to best interpret concentrations of B-type natriuretic peptide (BNP) or N-terminal (NT)-proBNP in ambulatory individuals with or without prior heart failure (HF).

2024年3月11日 · The natriuretic peptide system impacts salt and water handling and pressure regulation and may influence myocardial structure and function. B-type natriuretic peptide (BNP) is a natriuretic hormone initially identified in the brain but released primarily from the heart, particularly the ventricles.

For BNP, 100 pg/mL appears to be a consensus cutpoint. No clear consensus has emerged for NT-proBNP, but the age-adjusted cutpoints of 450 pg/mL for <50 years, 900 pg/mL for 50-75 years and 1,800 pg/mL for >75 years appear promising and merit greater scrutiny and validation.

When NT-proBNP is used as a clinical tool for diagnosis of acute decompensated HF, age-adjusted cut-offs are often applied and this has been shown in several studies to be appropriate. The PRIDE study [4] is a frequently quoted reference. The use of …

2022年3月3日 · A B-type natriuretic peptide (BNP) test or aminoterminal pro B-type natriuretic peptide (NT-proBNP) test gives your provider essential information about your heart health. It helps them diagnose heart failure, so they can develop a treatment plan.

Appropriately, a range of age-dependent cutpoints was considered. They propose new rule-in cutpoints of >450, >900, and >1,800 pg/ml for patients younger than 50 years of age, between 50 and 75 years of age, and older than 75 years of age, respectively.

2023年4月23日 · Like BNP, NT-proBNP concentrations vary by age; the normal threshold for those under 50 years of age is 450 pg/mL, while it is 900 pg/mL for those greater than 50 years of age. The clinical importance of measuring one peptide …

2018年4月1日 · NT-proBNP is particularly useful for “ruling in” HF among patients < 50 years of age. Among these patients, an NT-proBNP level > 450 pg/mL predicts a diagnosis of acute HF with an impressive specificity of 93.9% and a positive likelihood ratio of 14.08.

2011年11月17日 · The cutoff for NT-proBNP in the acute setting 300 pg/mL for patients under the age of 75. A value less than 300 has a strong negative predictive value for ruling out heart failure. The rule-out cutoff value for patients aged 75 or older is 450 pg/mL.