Emerging roles of Aurora-A kinase in cancer therapy resistance
2023年7月1日 · Aurora kinase A (Aurora-A), a serine/threonine kinase, plays a pivotal role in various cellular processes, including mitotic entry, centrosome maturation and spindle formation. Overexpression or gene-amplification/mutation of Aurora-A kinase occurs in different types of cancer, including lung cancer, colorectal cancer, and breast cancer.
Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for …
Deregulation of AURKB is observed in several tumors and its overexpression is frequently linked to tumor cell invasion, metastasis and drug resistance. AURKB has emerged as an attractive drug target leading to the development of small molecule inhibitors.
Aurora Kinase Inhibitors: Current Status and Outlook
2017年9月30日 · These observations led to a number of programs among academic and pharmaceutical organizations to discovering small molecule Aurora kinase inhibitors as anti-cancer drugs. This review will summarize the known Aurora kinase inhibitors currently in the clinic, and discuss the current and future directions.
Aurora Kinase Inhibitors in Oncology Clinical Trials: Current State …
The main side effects include febrile neutropenia, stomatitis, gastrointestinal toxicity, hypertension, and fatigue. Responses including complete remissions have been described in diverse, advanced malignancies, most notably ovarian cancer and acute myelogenous leukemia.
Safety, tolerability, and pharmacokinetics of Aurora kinase B
2023年3月4日 · Drug exposure was sustained for several days post-dose. The most common AZD2811-related adverse events (AEs) were fatigue (27.3%) at ≤200 mg/cycle and neutropenia (37.9%) at ≥400 mg/cycle.
Aurora Kinases and Potential Medical Applications of Aurora …
The most frequently encountered serious side effects were leukopenia, neutropenia, febrile neutropenia, neutropenic infections, azotemia and pyrexia. They concluded that their results provide ample justification for further clinical trials . Danusertib related renal side effects have been investigated in rats and dogs.
Aurora B: A new promising therapeutic target in cancer - PMC
Aurora B inhibitors have been obtained and are currently under clinical trials. However, antimitotic drugs frequently show the appearance of drug resistance, adverse side effects (neurotoxicity) and their clinical effects are not predictable. Aurora inhibitors lack neurotoxicity and could contribute to the treatment of human neoplasia (31-34).
Revisiting Aurora Kinase B: A promising therapeutic target for …
Aurora Kinase B inhibitors show promising biological results in in-vitro and in-vivo experiments. However, there are no inhibitors approved yet for clinical use, primarily because of the side effects associated with Aurora B inhibitors.
Critical risk-benefit assessment of the novel anti-cancer aurora a ...
Background: Many current anticancer chemotherapeutics suffer from significant side effects, which have led to the exploration of more targeted therapies. This resulted in the exploration of inhibitors of Aurora A kinase as a potential anti-cancer treatment.
Aurora kinase A inhibition reverses the Warburg effect and elicits ...
2021年9月1日 · Aurora kinase A (AURKA) has emerged as a drug target for glioblastoma (GBM). However, resistance to therapy remains a critical issue.