Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene. [4][5] Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP.

2024年12月24日 · ADCY8 (Adenylate Cyclase 8) is a Protein Coding gene. Diseases associated with ADCY8 include Dissociative Amnesia and Anxiety. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and Beta-2 adrenergic-dependent CFTR expression.

2022年3月20日 · Adenylyl cyclases (ADCYs) catalyze the production of cAMP from ATP, while phosphodiesterases (PDEs) degrade cAMP to 5′-AMP [3, 4]. This review summarizes the structure, regulation, expression and functions of ADCYs in the CNS. ADCYs are grouped into six different classes (class I-VI) based on their structural and domain organizations [5].

2025年2月8日 · ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion.

2024年11月1日 · A study using transgenic mice deficient in ADCY1 (ADCY1 −/−) or ADCY8 (ADCY8 −/−) found that LTP in IC stimulates the calcium signaling pathway by activating ADCY1 but not ADCY8. In conclusion, the study demonstrates that LTP …

ADCY8 is the most widely reported subtype implicated in cervical intraepithelial neoplasia. Regarding cervical cancer, miR-181b (a miRNA) promotes the growth of cervical cancer cells and inhibits apoptosis by increasing mRNA degradation and decreasing intracellular cAMP levels, which may be caused by binding to the 30′UTR#2 of AC9 ( 96 ).

2024年10月28日 · Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of …

Expression of the calcium-stimulated adenylyl cyclase ADCY8 is regulated by glucose and the enzyme is capable of integrating signals from multiple pathways. It may thus have an important role in glucose-induced signalling and glucose homeostasis.

The type 1 and 8 adenylyl cyclase (ADCY1 and ADCY8) exclusively account for Ca2+-stimulated cyclic AMP (cAMP) production and regulate activity-dependent synaptic modification. In this study, we examined distinct forms of synaptic plasticity in the ...

2025年1月4日 · ADCY8 is required for the physiological activation of glucose-induced signalling pathways in beta cells, for glucose tolerance and for hypothalamic adaptation to a high-fat diet via regulation of islet insulin secretion.