2020年10月21日 · ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins.

2024年12月24日 · ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Cone-Rod Dystrophy 2 . Among its related pathways are Extracellular matrix organization and Collagen chain trimerization .

2020年10月21日 · ADAM9 (A disintegrin and a metalloprotease 9) is a membrane-anchored protein that participates in a variety of physiological functions, primarily through the disintegrin domain for adhesion and the metalloprotease domain for ectodomain shedding of a wide variety of cell surface proteins.

2024年11月6日 · Immunohistochemistry (IHC) staining from 90 pathologically verified samples proved the positive correlation between ADAM9 and tumor stages and proved the higher expression of ADAM9 correlated...

ADAM9 is a key target of miR-126 and is regulated by the ‘DNMT1-miR-126 pathway’ in ESCC. ADAM9 is overexpressed in ESCC cell line, and its mRNA level is negatively correlated with miR-126 level.

2024年8月1日 · ADAM9 plays a significant role in the proliferation, invasion, metastasis, angiogenesis, and even immune evasion of various malignant tumors, such as liver cancer, breast cancer, lung cancer, gastric cancer, kidney cancer, and prostate cancer.

2024年5月16日 · Our findings identify a role for ADAM9 in the innate antiviral response, specifically MDA5-mediated IFN production, which protects against virus-induced cardiac damage, and provide a potential ...

2024年1月24日 · Suppression of ADAM9 by a small-molecule inhibitor restricts disease progression in spontaneous models, and combination with gemcitabine elicits dramatic regression of patient-derived tumors.

2024年6月6日 · ADAM9: A regulator between HCMV infection and function of smooth muscle cells. Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells.

Explore the intricacies of ADAM9, a crucial gene encoding a disintegrin and metalloproteinase domain 9 protein. Discover its structure, function, regulation, and involvement in various biological processes, including cancer and development.