2024年12月24日 · ACVR2A (Activin A Receptor Type 2A) is a Protein Coding gene. Diseases associated with ACVR2A include 2Q23.1 Microduplication Syndrome and Fibrodysplasia Ossificans Progressiva. Among its related pathways are Signaling by TGFB family members and Signaling by NODAL.

2025年2月8日 · Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

2017年8月18日 · Here, we generated mice with conditional deletion of activin receptor (ACVR) type 2A, ACVR2B, or both, in osteoblasts, to determine the contribution of activin receptor signaling in regulating bone mass. Immunohistochemistry localized ACVR2A and ACVR2B to osteoblasts and osteocytes.

2024年4月1日 · ACVR2A and ACVR2B are constitutively active type II receptors which also contain an extracellular ligand binding domain, and a larger serine/threonine kinase domain (Fig. 1 C). Each type I/type II receptor combination can bind more than one activin dimer to form an active signaling complex.

BMPR2 shares functional similarities with the type II activin receptors ACVR2A and ACVR2B, as it interacts with an overlapping group of TGF-β family growth factors (GFs). However, how BMPR2 recognizes GFs remains poorly understood.

2025年1月4日 · Title: Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.

2018年9月8日 · Aims: Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis.

2025年2月8日 · Go to Variation Viewer for ACVR2A variants Summary This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes.

2015年6月6日 · Activin A was able to counteract BMPs that signal through the type 2 receptors ACVR2A and ACVR2B in combination with ALK2, but not BMPs that signal through BMPR2 in combination with ALK3 and ALK6. Conclusions: We propose that one important way that activin A regulates cell behavior is by antagonizing BMP-ACVR2A/ACVR2B/ALK2 signaling.

2025年1月6日 · ACVR2A Regulates the Migration and Invasion of Trophoblast Cells through TCF7/c-JUN Pathway. Previous experiments have confirmed the pivotal role of ACVR2A in regulating the fundamental functions of trophoblast cells. Knocking out ACVR2A significantly hindered the migration, proliferation, invasion, and clonal formation of trophoblast cells.