2024年12月24日 · ACP1 (Acid Phosphatase 1) is a Protein Coding gene. Diseases associated with ACP1 include Bubonic Plague and Anemia, Congenital, Nonspherocytic Hemolytic, 1. Among its related pathways are EPHA2 forward signaling and Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction.

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene. The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins.

关于 acp1 Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:264,947-278,283 (from NCBI) This gene has 13 transcripts (splice variants), 179 orthologues and 1 paralogue.

2024年1月31日 · We found ACP1 up-regulated in human prostate tumors and ACP1 expression inversely correlated with overall survival. Using CRISPR-Cas9–generated LMPTP knockout C4-2B and MyC-CaP cells, we identified LMPTP as a critical promoter of prostate cancer (PCa) growth and bone metastasis.

拟南芥 ACP1 是种子中优先表达的 ACP 基因。Branen 等人构建了 35S 启动子驱动的带有 ACP1 和其上游 400bp 序列的植物表达载体,转基因的拟南芥植株在叶组织中该基因的表达增加了 3-8 倍,而在种子中没有明显变化。

2025年2月9日 · the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. Data indicate that ACP1 rs11553742*T with increased susceptibility in systemic lupus erythematosus (SLE) patients.

2024年9月19日 · These data support that PTPN22 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A, B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults. Title: No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients.

2024年10月28日 · Clinical resource with information about ACP1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2024年10月2日 · The acid phosphatase 1 (ACP1) gene encodes low-molecular-weight protein tyrosine phosphatase, which is overexpressed in prostate cancer (PC) and a potential therapeutic target. We analyzed ACP1 expression in primary/metastatic PC and its association with molecular profiles and clinical outcomes.

参与化学突触传递。位于神经元投射中。这个基因的人类同源物与几种疾病有关，包括注意力缺陷多动障碍；行为障碍；糖尿病（多种）；糖尿病性视网膜病变；和肥胖症。与人类acp1（酸性磷酸酶1）正交。[由基因组资源联盟，2022年4月提供]