Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene. [5] The ACOT1 gene is located on the 14th chromosome, with its specific localization being 14q24.3. It contains 7 exons. [5] The protein encoded by this gene contains 410 amino acids, and forms a homodimer with another chain. [6] .

Dec 24, 2024 · ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Diseases associated with ACOT1 include Aztreonam Allergy and Cefaclor Allergy. Among its related pathways are Fatty acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and obsolete palmitoyl-CoA hydrolase activity.

Hepatic acyl-CoA thioesterase 1 (ACOT1) catalyzes the conversion of acyl-CoAs to fatty acids (FAs) and CoA. We sought to determine the role of ACOT1 in hepatic lipid metabolism in C57Bl/6J male mice 1 week after adenovirus-mediated Acot1 knockdown.

Feb 8, 2025 · Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Feb 2025]

ACOT1 is a cytosolic enzyme with substrate selectivity for long chain (C12–C20) saturated-and monounsaturated acyl-CoAs. It is expressed mainly in liver, kidney, lung and heart in mouse [11, 16].

We identified seven DARs including a candidate enhancer for the ACOT1 gene that regulates the balance of acyl-CoA and free fatty acids (FFAs) in the cytoplasm. The relevance of ACOT1 regulation in T2D was supported by the analysis of transcriptomics and …

Aug 1, 2010 · ACOT1, ACOT2 and ACOT4 have distinct subcellular localisation patterns and substrate specificity. ACOT1 is cytosolic and primarily responsible for the metabolism of long-chain acyl-CoAs [1, 14].

Feb 18, 2014 · Fluorescence-tagged ACOT1 showed a diffuse pattern of expression in transfected human skin fibroblasts. Brocker et al. (2010) reviewed the ACOT gene family. They stated that ACOT1 contains an N-terminal acyl-CoA thioester hydrolase domain and a C-terminal esterase-lipase domain.

Sep 15, 2020 · The beneficial role of Acot1 may be related to its biochemical function by shaping the lipid composition. In all, Acot1 may become a potential treating target in preventing DIC by...

The Thioesterase <i>ACOT1</i> as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver. ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma. Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.