Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the ACKR1 gene. [5] [6] [7] The Duffy antigen is located on the surface of red blood cells, and is named after the patient in whom it was discovered.

Dec 24, 2024 · ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Diseases associated with ACKR1 include White Blood Cell Count Quantitative Trait Locus 1 and Malaria. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Atypical chemokine receptor 1 (ACKR1), previously known as the Duffy antigen receptor for chemokines (DARC), is a key regulator that binds chemokines involved in inflammatory responses and cancer proliferation, angiogenesis, and metastasis.

Sep 20, 2024 · The ACKR1 gene encodes the Duffy antigen receptor for chemokines (DARC), which is expressed on red blood cells (RBCs), endothelial cells, and other cell types.

Mar 8, 2025 · Title: Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles. Presence of ""ACKR1/DARC null"" polymorphism in Arabs from Jisr az-Zarqa with benign ethnic neutropenia.

Dec 18, 2024 · Targeting ACKR1 through both functional and pharmacological approaches effectively suppressed TAAD progression and extended survival in TAAD mice, offering promising new intervention strategies for clinical evaluation.

Oct 11, 2013 · Atypical chemokine receptors (ACKRs) are structurally related to conventional chemokine receptors but are unable to initiate classical chemokine receptor signalling after ligand binding.

May 7, 2024 · There are four receptors currently with formal ACKR designation: ACKR1 (formerly known as Duffy antigen receptor for chemokines (DARC)), ACKR2 (formerly known as D6 or CCBP2), ACKR3 (also known...

Sep 24, 2024 · Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

Tumor-specific immune response is an important aspect of disease prognosis and ultimately impacts treatment decisions for innovative immunotherapies. The Atypical Chemokine Receptor 1 (ACKR1/DARC) gene, plays a pivotal role in immune regulation and ...