Chemistry of acetyl transfer by histone modifying enzymes: …
2007年8月13日 · In this review, we will discuss what we have learned from the structures and related biochemistry of HATs and HDACs and the implications of these findings for the design of protein effectors to...
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit
2024年5月17日 · Acetyl-CoA synthetase short-chain family member 1 (ACSS1; previously known as AceCS2) catalyzes the ligation of acetate and CoA to generate acetyl-CoA in the mitochondrial matrix, enabling the utilization of acetate for energy during conditions of nutrient deprivation .
Structural and chemical biology of deacetylases for ... - Nature
2018年12月5日 · Deacetylation is the removal of an acetyl group and occurs on a plethora of targets and for a wide range of biological reasons. Several pathogens deacetylate their surface carbohydrates to...
Writers and Readers of Histone Acetylation: Structure, …
Histone acetylation marks are written by histone acetyltransferases (HATs) and read by bromodomains (BrDs), and less commonly by other protein modules. These proteins regulate many transcription-mediated biological processes, and their aberrant activities are correlated with several human diseases.
Sink into the Epigenome: Histones as repositories that influence ...
In this review, we will focus on reciprocal relationships between the epigenome and metabolism, mainly using histone methylation and acetylation as examples, and discuss how cellular SAM and acetyl-CoA levels affect chromatin states.
A chemical catalyst enabling histone acylation with endogenous
2023年9月22日 · For example, histone acetyltransferases (HATs) promote acetylation of histone lysine residues using the endogenous thioester acetyl reagent acetyl-CoA (Ac-CoA) and regulate the histone...
Structure of the p300 Histone Acetyltransferase Bound to Acetyl ...
2014年6月3日 · Here, we report a structural characterization of different reaction states in the p300 activity cycle. We present the structures of p300 in complex with an acetyl-CoA substrate, a CoA product, and an acetonyl-CoA inhibitor.
Frontiers | Post-translational Protein Acetylation: An Elegant ...
Acetylation is a modification that can dramatically change the function of a protein through alteration of its properties, including hydrophobicity, solubility, and surface properties, all of which may influence protein conformation and interactions with substrates, cofactors and other macromolecules.
Acetylcarnitine shuttling links mitochondrial metabolism to histone ...
2023年5月3日 · Using stable isotope tracing, we show that both glucose and fatty acids contribute to acetyl-CoA pools and histone acetylation in DKO cells and that acetylcarnitine shuttling can transfer two-carbon units from mitochondria to cytosol.
Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme …
2022年12月12日 · In this study, we demonstrate that ATP citrate lyase (Acly), which metabolizes citrate to generate cytosolic acetyl-CoA and is of clinical interest, can regulate chromatin accessibility to limit myeloid differentiation.