- Glucuronidation is the main pathway of acetaminophen metabolism, followed by sulfation and a minor contribution from the oxidation route.了解详细信息：Glucuronidation is the main pathway of acetaminophen metabolism, followed by sulfation and a minor contribution from the oxidation route.pmc.ncbi.nlm.nih.gov/articles/PMC4498995/Acetaminophen metabolizes in liver through three main pathways: glucuronidation (shown in purple), sulfation (shown in green) and phase I oxidation (shown in red).www.researchgate.net/figure/Pathways-for-acetami…Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways.pubmed.ncbi.nlm.nih.gov/18811827/
PharmGKB summary: Pathways of acetaminophen metabolism at …
Glucuronidation is the main pathway of acetaminophen metabolism, followed by sulfation and a minor contribution from the oxidation route. Oxidation by CYP isozymes yields a reactive metabolite NAPQI that is detoxified by the glutathione pathway.
Pathway PA165986279 - PharmGKB
Take a short tour of the pathway page. hide banner. Search. Menu. Publications News (opens in new window) Downloads Contact. Focus. Intro to Focus. Pediatric Focus. Pediatric Help Pediatric Dashboard. Help. FAQs Page Tour. …
Acetaminophen - StatPearls - NCBI Bookshelf
2024年1月11日 · Metabolism: Acetaminophen undergoes primarily hepatic metabolism via first-order kinetics, utilizing 3 distinct pathways—conjugation with glucuronide, conjugation with sulfate, and oxidation facilitated by the …
The biochemistry of acetaminophen hepatotoxicity and …
We have created a whole body model of acetaminophen transport and metabolism that includes the details of the biochemical pathways of acetaminophen metabolism in the liver and peripheral tissues. The model was …
Analgesic Effect of Acetaminophen: A Review of Known and Novel ...
However, our group recently revealed a new analgesic mechanism of acetaminophen, using behavioral measures, in vivo and in vitro whole-cell patch-clamp recordings with rats, wherein …
Acetaminophen Metabolism Pathway - PubChem
2019年5月30日 · Acetaminophen (APAP) is metabolized primarily in the liver. Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, …
Acetaminophen Action Pathway - PubChem
2019年5月30日 · Acetaminophen (also named paracetamol or APAP) is not a Nonsteroidal anti-inflammatory drugs (NSAIDs). However, it still can be used to treat pain and fever. …
PharmGKB summary: pathways of acetaminophen metabolism at …
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses Pharmacogenet Genomics . 2015 Aug;25(8):416-26. doi: …
Metabolism and Disposition of Acetaminophen: Recent …
2013年3月6日 · Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism …
Acetaminophen Pathway, Pharmacokinetics - PubChem
2012年11月8日 · Biological pathway information for Acetaminophen Pathway, Pharmacokinetics from PharmGKB.