ACER2 - Wikipedia
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. [5] The ACER2/ sphingosine pathway plays an important role in …
ACER2 Gene - GeneCards | ACER2 Protein | ACER2 Antibody
Dec 24, 2024 · ACER2 (Alkaline Ceramidase 2) is a Protein Coding gene. Diseases associated with ACER2 include Farber Lipogranulomatosis and Spinal Muscular Atrophy With …
Alkaline ceramidase 2 is a novel direct target of p53 and induces ...
Mar 15, 2017 · In the present study, we have identified ACER2 promoter and also found that ACER2 is a direct transcriptional target gene of p53. Furthermore, we have demonstrated that …
The role of ACER2 in intestinal sphingolipid metabolism and ...
Nov 22, 2024 · ACER2-mediated sphingolipid signaling, particularly through the SphK/S1P pathway, influences cancer development by modulating immune responses, inflammation, and …
Alkaline ceramidase 2 and its bioactive product sphingosine are …
Herein we demonstrate that DNA damage increases sphingosine levels in tumor cells by upregulating alkaline ceramidase 2 (ACER2) and that the upregulation of the …
Maternal and fetal alkaline ceramidase 2 is required for placental ...
Herein we report that alkaline ceramidase 2 (ACER2) plays a key role in sustaining the integrity of the placental vasculature by regulating the homeostasis of sphingolipids in mice. The mouse …
ACER2 alkaline ceramidase 2 [ Homo sapiens (human) ]
Title: Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation. Results suggest that the ACER2/sphingosine pathway mediates …
Substrate Specificity, Membrane Topology, and Activity Regulation …
Human alkaline ceramidase 2 (ACER2) plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells. Here we report its biochemical characterization, …
Tumor suppressor p53 links ceramide metabolism to DNA …
Dec 11, 2017 · Herein we demonstrate that human alkaline ceramidase 2 (ACER2) is a novel transcriptional target of p53 and that its transactivation by p53 mediates the DDR. We found …
Alkaline ceramidase 2 is a novel direct target of p53 and induces ...
ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the transcriptional …
Maternal and fetal alkaline ceramidase 2 is required for placental ...
Herein we report that alkaline ceramidase 2 (ACER2) plays a key role in sustaining the integrity of the placental vasculature by regulating the homeostasis of sphingolipids in mice. The mouse …
340485 - Gene ResultACER2 alkaline ceramidase 2 [ (human)]
Feb 8, 2025 · Depletion of the essential autophagy gene ATG5 revealed that ACER2-induced autophagy facilitates its effect on apoptosis. Results suggest that the ACER2/sphingosine …
Acer2 alkaline ceramidase 2 [ (house mouse)] - National Center …
Feb 8, 2025 · Using genome-wide association analyses, we identified eight gene-containing loci, including a locus containing Acer2, which encodes a ceramidase and is specifically expressed …
Alkaline Ceramidase 2 (ACER2) and Its Product …
In this study we explore the role of ACER2, ACER3, and their homologue, the human alkaline ceramidase 1 (ACER1) in mediating the 4-HPR-induced generation of DHS and the …
Human alkaline ceramidase 2 promotes the growth, invasion, and ...
Human alkaline ceramidase 2 (ACER2), a key enzyme that regulates hydrolysis of cellular ceramides, affects cancer cell survival, however its role in HCC has not been well …
Alkaline ceramidase 2 (ACER2) promotes tumor angiogenesis and …
Apr 1, 2011 · Here we report that the human alkaline ceramidase 2 (ACER2), which catalyzes the generation of the S1P precursor sphingosine, plays important roles in tumor angiogenesis and …
Alkaline ceramidase 2 is a novel direct target of p53 and induces ...
Mar 15, 2017 · ACER2 is a critical sphingolipid metabolizing enzyme, and has been shown to be remarkably up-regulated following various stimuli such as DNA damage. However, the …
Alkaline ceramidase family: The first two decades - ScienceDirect
Feb 1, 2021 · Here we discuss the discovery of the ACER family, the biochemical properties, structures, and catalytic mechanisms of its members, and its role in regulating sphingolipid …
ACER2 forms a cold tumor microenvironment and predicts the …
Mar 1, 2023 · Alkaline ceramidase 2 (ACER2) was a sphingolipid metabolizing enzyme localized to the Golgi complex, which could convert ceramide to sphingosine in vivo ( Sun et al., 2010 ). …
ACER2 alkaline ceramidase 2 - NIH Genetic Testing Registry …
Jan 25, 2024 · Clinical resource with information about ACER2, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, …