The abscission checkpoint regulates the ESCRT membrane fission machinery and thereby delays cytokinetic abscission to protect genomic integrity in response to residual mitotic errors. The …

The abscission checkpoint contributes to the fidelity of chromosome segregation by delaying completion of cytokinesis (abscission) when there is chromatin lagging in the intercellular …

2020年4月22日 · We propose that the ESCRT-III machinery must be physically coupled to a membrane protein at the cytokinetic abscission site for efficient scission, uncovering common …

2011年2月10日 · Here, we examined intermediate stages of abscission in human cells by using live imaging, three-dimensional structured illumination microscopy, and electron tomography. …

2020年11月8日 · Reviewing knowledge obtained from in vitro as well as in vivo experiments, we give a brief overview on the role of ESCRT components in abscission mainly focussing on …

The abscission checkpoint (also referred as the NoCut checkpoint) is an evolutionarily conserved pathway in eukaryotic cells that delays abscission in response to various signals including the …

Here, we examined intermediate stages of abscission in human cells, using live imaging, three-dimensional structured illumination microscopy, and electron tomography. We identified …

2024年5月13日 · Abscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB) connecting two daughter cells. Abscission requires tight control of the recruitment and...

2012年4月4日 · Here, we show that Charged Multivesicular Body (MVB) Protein 4C (CHMP4C), a human ESCRT-III subunit, is involved in abscission timing. This function correlated with its …

Timing of cytokinetic abscission is monitored by a molecular machinery termed the abscission checkpoint. This machinery delays abscission in cells with persistent chromatin in the …