Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene. [5][6][7] The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.

2024年12月24日 · ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a Protein Coding gene. Diseases associated with ABCC5 include Currarino Syndrome and Primary Angle-Closure Glaucoma. Among its related pathways are Glycosaminoglycan metabolism and Blood-Brain Barrier and Immune Cell Transmigration: Overview.

2025年2月8日 · ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations. ABCC5 functions as a mediator of breast cancer skeletal metastasis. ABCC5 expression in breast cancer cells is important for efficient osteoclast-mediated bone resorption.

2024年11月4日 · ABCC5 mediates drug resistance and promotes tumour proliferation and metastasis in different types of cancer (Chen et al., 2022; Chen et al., 2021a). Fewer studies have been conducted on ABCC5, and there is minimal literature detailing the role of ABCC5 in cancer drug resistance.

Here, we have isolated three novel ABCC5 splice variants and characterized their role in the regulation of ABCC5 gene expression. Two additional exons within intron 5 of the ABCC5 gene were identified; one of the exons exhibits alternative donor splice sites.

2024年6月17日 · ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. Pan-cancer analysis and single-cell analysis revealed the role of ABCC5 transporter in hepatocellular carcinoma. Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues.

2024年11月5日 · As a member of the family of ABC transporter proteins, ABCC5 (ATP Binding Cassette Subfamily C Member 5) reduces the intracellular concentration of a drug and its subsequent effectiveness using an ATP-dependent method to pump the drug out of the cell.

2024年12月24日 · ABCC5-AS1 (ABCC5 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ABCC5-AS1 include Currarino Syndrome.

The present study shows that the ATP-dependent multidrug resistance protein-5 (MRP5, ABCC5) confers resistance to 5-FU by transporting the monophosphate metabolites. MRP5- and vector-transfected human embryonic kidney (HEK) cells were employed in these studies.

Description: Homo sapiens ATP binding cassette subfamily C member 5 (ABCC5), transcript variant 1, mRNA. (from RefSeq NM_005688) RefSeq Summary (NM_005688): The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.