Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. [5][6] Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete …

2024年12月24日 · ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with ASCL1 include Haddad Syndrome and Congenital …

2022年4月27日 · ASCL1 acts as a driver of the lineage plastic, neuronal transcriptional program to support treatment resistance and neuroendocrine phenotype. Targeting ASCL1 switches …

2025年2月8日 · Ascl1 modulates multiple steps of oligodendrocyte precursor cell development in the postnatal brain and in response to demyelinating insults. Ascl1 directly regulates …

2019年5月13日 · We found that Ascl1 and Neurog2 generate neurons by binding to largely different sets of genomic sites when expressed in similar chromatin and cellular contexts. …

In this study, we focus on ASCL1, a class II basic‐helix–loop–helix (bHLH) transcription factor that forms a heterodimer with class I bHLH E‐proteins (such as E47/TCF3) to activate specific …

ASCL1, also known as a proneural bHLH transcription factor, is a protein that is expressed in oligodendrocyte progenitor cells (OPCs) during both embryonic and early postnatal stages. It …

2014年10月14日 · We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the …

2025年1月4日 · Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and …

2 天之前 · Inducible co-expression models of all combinations of ASCL1, NEUROD1, POU2F3, YAP1, and ATOH1 using SCLC cell lines showed that some expression combinations, such as …