ALK1 signaling in development and disease: new paradigms
In this review, we present an updated view of the mechanism of ALK1 signaling, put forth a unified hypothesis to explain the cellular missteps that lead to AVMs associated with ALK1 deficiency, …
ALK1 as an emerging target for antiangiogenic therapy of cancer
Jun 30, 2011 · Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the …
ALK Gene - GeneCards | ALK Protein | ALK Antibody
Dec 24, 2024 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related …
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 …
Apr 1, 2020 · Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in...
Role of activin receptor-like kinase 1 in vascular development and ...
Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically expressed in …
Activin receptor-like kinase (ALK)1 is an antagonistic ... - PubMed
Activin receptor-like kinase-1 (ALK1) induces Smad1/5 phosphorylation, leading to an increase in endothelial cell proliferation and migration, while ALK5 promotes Smad2/3 activation and …
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis
Jun 2, 2023 · Genetic deletion of, or selective monoclonal antibody binding to, activin receptor-like kinase 1 (ALK1) inhibits LDL transcytosis into the endothelium and prevents the development of...
ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans …
Feb 15, 2018 · In this work, we report that a reduction in ALK1 gene dosage (heterozygous ALK1 +/− mice) results in enhanced retinal endothelial cell proliferation and vascular hyperplasia at …
ALK1 as an emerging target for antiangiogenic therapy of cancer
Activin receptor-like kinase 1 (ALK1) is an EC-restricted receptor of the large TGF-β family. 1 Herein, we will review our current understanding of ALK1 signaling and the potential of ALK1 …
Specificity and Structure of a High Affinity Activin Receptor-like ...
Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β superfamily, is an important regulator of normal blood vessel development as well as …
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