2022年3月18日 · We identified paclitaxel as a universal adjuvant that efficiently potentiated ADCP by a variety of anticancer antibodies in multiple cancers. Rather than eliciting cytotoxicity on cancer cells, paclitaxel polarized macrophages toward a state with enhanced phagocytic ability.

ADCP is the mechanism by which antibody-opsonized target cells activate the FcγRs on the surface of macrophages to induce phagocytosis, resulting in internalization and degradation of the target cell through phagosome acidification.

The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators.

2019年2月28日 · The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators.

2021年1月1日 · Resiquimod (R848), an immune system activating agent, has been shown to stimulate the M1 type macrophages, and re-educate the TAMs from M2 type to M1 type. By treating TAMs with R848, the ADCP response increased significantly in vitro and in in vivo mouse xenograft models.

Antibody-dependent cellular phagocytosis (ADCP) is a mechanism by which macrophages contribute to antitumor potency of monoclonal antibodies. Herein, we studied the NK cell independent effect of elotuzumab on tumor-associated macrophages using a xenograft tumor model deficient in NK and adaptive immune cells.

2024年8月1日 · ADCP is a cellular process by which antibody-opsonized targets (including pathogens and cells) are engulfed by phagocytes. In ADCP, phagocytes are normally effector immune cells with phagocytic potential, such as macrophages, monocytes, and dendritic cells as well as neutrophils (Tay et al., 2019).

Antibody-dependent cellular phagocytosis (ADCP) is the immunological process of antibody-stimulated engulfment of tumor cells by phagocytic immune cells, such as monocytes and macrophages. This results in specific internalization and …

2021年9月4日 · In this chapter, we describe a protocol that measures ADCP activity by labeling target cells with a pH-sensitive dye that fluoresces brightly in mature phagosomes. The ADCP activity of therapeutics is then measured via flow cytometry.

Antibody-dependent cellular cytotoxicity & phagocytosis (ADCC & ADCP) InvivoGen offers convenient ADCC and ADCP cellular assays to screen monoclonal antibody effector functions. ADCC and ADCP are two major modes of action of therapeutic monoclonal Abs (mAbs).