Dec 24, 2024 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone …

Aug 9, 2021 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on …

May 30, 2015 · In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on …

Adamts5-/-mice clearly show increased weight loss and higher viral titres throughout the course of influenza virus infection along with impaired CD8 + T cell migration and immunity. Results …

Domain mapping and mechanistic studies revealed that ADAMTS5 inhibits B16 tumorigenesis through its TSR1 by suppressing tumor angiogenesis, likely by down-regulating pro …

Feb 19, 2025 · ADAMTS5 is downregulated in gastric cancer and suppresses tumor metastasis and angiogenesis; High ADAMTS5 expression is associated with osteoarthritic cartilage …

The major proteoglycan in the extracellular matrix—aggrecan—is primarily cleaved by the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of genes.1 …

Nov 21, 2016 · Although overexpression of ADAMTS5 has been reported in glioblastoma, and head and neck cancer, little has been demonstrated in colorectal cancer types. The present …

May 25, 2017 · To determine whether ADAMTS5 and matrilin 2 levels are altered in calcified aortic valves, we analyzed protein levels of ADAMTS5 and matrilin 2 in normal valve tissues …

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We …