A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. [5][6] ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.

2024年12月24日 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone Deterioration Disease. Among its related pathways are O-linked glycosylation of mucins and Endochondral ossification with skeletal dysplasias.

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA.

Adamts5-/-mice clearly show increased weight loss and higher viral titres throughout the course of influenza virus infection along with impaired CD8 + T cell migration and immunity. Results Phenotyping of Adamts5-/-Immune Cells. ADAMTS enzymes are widely distributed in human adult tissues and play a key role in normal cellular function.

2015年5月30日 · In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur.

Domain mapping and mechanistic studies revealed that ADAMTS5 inhibits B16 tumorigenesis through its TSR1 by suppressing tumor angiogenesis, likely by down-regulating pro-angiogenic factors such as vascular endothelial growth factor (VEGF), placenta growth factor (PlGF), and platelet-derived endothelial growth factor (PD-ECGF) in the tumor milieu.

ADAMTS5 (Abbaszade et al., 1999; Hurskainen et al., 1999) has a major role in degradation of the cartilage proteoglycan, aggrecan in arthritis (Abbaszade et al., 1999). The most compelling evidence supporting this role comes from genetic interference with …

2021年11月22日 · Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the most abundant proteases. ADAMTS5 cleaves chondroitin sulfate proteoglycans such as versican. The contribution of ADAMTS5 and its substrate versican to HF is unknown.

2022年1月14日 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. Herein, we provide information on ADAMTS5 gene research and the latest insights into OA treatment strategies.

2021年8月9日 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA.