ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin -like domain, and a thrombospondin type 1 (TS) motif.

2024年12月24日 · ADAMTS5 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5) is a Protein Coding gene. Diseases associated with ADAMTS5 include Osteoarthritis and Bone Deterioration Disease . Among its related pathways are O-linked glycosylation of mucins and Endochondral ossification with skeletal dysplasias .

2021年8月9日 · As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an updated insight on the regulation of ADAMTS5 and newly discovered therapeutic strategies for OA.

ADAM(A Disintegrin and Metallo-proteinases)和ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) 是基质锌依赖的金属蛋白酶，它们一起被称为 adamalysins。ADAM 金属蛋白酶是跨膜和分泌蛋白，而 ADAMTS 是分泌形式。 Adamalysins 主要存在于细胞外基质 (ECM) 中，它们可以通过间隔域 (SD) 或血小板结合蛋白基序 (TS ...

2021年7月5日 · ADAMTS5 的过度激活涉及衰老、遗传、炎症和机械应激，从而导致 OA 的发病机制。观察到多种分子信号通路调节 ADAMTS5 的表达，即 Runx2、YAP/TAZ、Notch、Wnt、NF-κB 和其他炎症信号通路。然而，分子调控网络尚未阐明，ADAMTS5 的时空表达模式仍未阐明。

总结 介绍 基质金属蛋白酶 (mmp) 和“聚集蛋白聚糖酶”是一种解聚素和具有血小板反应蛋白基序的金属蛋白酶 (adamts)，它们通过降解细胞外基质 (ecm) ii 型胶原蛋白和蛋白聚糖在骨关节炎 (oa) 中发挥关键作用，因此oa 治疗的潜在目标。目的 本文旨在全面综述其他鲜为人知的 adamts 和相关的阿达马溶素 ...

2025年2月19日 · ADAMTS5 is downregulated in gastric cancer and suppresses tumor metastasis and angiogenesis; High ADAMTS5 expression is associated with osteoarthritic cartilage deterioration. ADAMTS5 was uniquely downregulated in Barlow's Disease.

含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶ADAMTSs(a disintegrin and metallo-proteinase with thrombospondin motifs)是一类新的Zn2+依赖的金属蛋白酶家族,广泛存在于哺乳动物和无脊椎动物体内.从1997年发现第一个ADAMTSs家族成员以来,迄今共有19个成员被发现,在保持凝血系统的稳态、器官生成、炎症、生育等 ...

Adamts5-/-mice clearly show increased weight loss and higher viral titres throughout the course of influenza virus infection along with impaired CD8 + T cell migration and immunity. Results Phenotyping of Adamts5-/-Immune Cells. ADAMTS enzymes are widely distributed in human adult tissues and play a key role in normal cellular function.

2015年5月30日 · Adamts5−/− mice have enlarged heart valves by late fetal stages, correlating with reduced versican cleavage . This phenotype was rescued by in vivo reduction of the level of versican by intercrossing with Vcan heterozygous mice. Thus, ADAMTS5 is required during heart development for the clearance of the early versican-rich matrix.