ADAMTS13 - Wikipedia
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a …
The role of ADAMTS13 testing in the diagnosis and management …
2018年8月30日 · ADAMTS13 deficiency is the cause of TTP but also has a significant role in the pathophysiology, diagnosis, and prognosis of other TMAs and thrombotic disorders, such as stroke and myocardial infarction.
ADAMTS13 gene - MedlinePlus
The ADAMTS13 gene provides instructions for making an enzyme that is involved in regulating blood clotting. After an injury, clots normally protect the body by sealing off damaged blood vessels and preventing further blood loss.
ADAMTS-13 in the Diagnosis and Management of Thrombotic ...
In Panel A, in normal subjects, ADAMTS-13 (von Willebrand factor–cleaving metalloprotease) molecules attach to binding sites on endothelial cell surfaces and cleave unusually large multimers of von Willebrand factor as they are secreted by stimulated endothelial cells.
ADAMTS13: origins, applications, and prospects - PubMed
ADAMTS13 is an enzyme that acts by cleaving prothrombotic von Willebrand factor (VWF) multimers from the vasculature in a highly regulated manner. In pathologic states such as thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies (TMAs), VWF can bind to the endothelium and …
ADAMTS13 Gene - GeneCards | ATS13 Protein | ATS13 Antibody
2024年12月24日 · ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13) is a Protein Coding gene. Diseases associated with ADAMTS13 include Thrombotic Thrombocytopenic Purpura, Hereditary and Thrombotic Thrombocytopenic Purpura.
ADAMTS13 and von Willebrand Factor in Thrombotic …
ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular injury.
ADAMTS13 - an overview | ScienceDirect Topics
ADAMTS13 is a plasma protease that cleaves circulating VWF between Tyr 1605 and Met 1606 in the A2 domain. Its main target is the ULvWF multimers, which spontaneously bind GPIbα on platelets. ADAMTS13 cleaves ULvWF multimers when there is sufficient shear to unfold the A2 domain and to expose the cleavage site.
Structure-function and regulation of ADAMTS13 protease - PMC
Structure-function studies demonstrate that the N-terminal portion of ADAMTS13 (MDTCS) is necessary and sufficient for proteolytic cleavage of VWF under various conditions and attenuation of arterial/venous thrombosis after oxidative injury.
The Role of ADAMTS13 Testing in the Work up of Suspected …
ADAMTS13, a protease also known as von Willebrand factor (VWF) cleaving protease, regulates the size of VWF multimers, and is an important mediator of platelet adhesion. ADAMTS13 regulates VWF size by cleaving a specific peptide bond in the A2 domain.