Mar 18, 2022 · Here we show that the enzyme acetyl-CoA-carboxylase 1 (ACC1), which couples glucose metabolism to lipogenesis, plays a key role in the regulation of glucagon secretion. …

Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …

One of the most widely reported AMPK functions is the regulation of lipid metabolism through phosphorylation of acetyl-CoA carboxylase 1 (ACC1) at Ser 79 and ACC2 at Ser 212. ACC1 …

ACC1 (acetyl coenzyme A carboxylase 1) is a key enzyme that has been recently found to propagate CD4 + T cell-associated inflammation by mediating de novo fatty acid synthesis; …

Jun 13, 2018 · Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the outer mitochondrial membrane and controls fatty …

The molecular mechanism underlying the dynamic organization of ACCs is largely unknown. Here, we determined the cryo–electron microscopy (EM) structure of human ACC1 in its …

Our data demonstrate that ACC1 inhibition promotes Treg differentiation and long-term stability in vitro and in vivo. Thus, ACC1 serves as a dual metabolic and epigenetic hub, regulating …

Acetyl CoA carboxylase (ACC) catalyzes conversion of acetyl CoA to malonyl CoA, which regulates both biosynthesis and breakdown of long chain fatty acids. Two isozymes, ACC1 …

Mar 10, 2022 · Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of …

Feb 8, 2025 · We for the first time verified that ACC1 mRNA was upregulated in non-small-cell lung cancer (NSCLC), and higher ACC1 level was correlated with poor outcome in lung cancer …