Autoantibodies against several aminoacyl-transfer-RNA synthetases have been described in patients with myositis; anti-threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and compare them with previously reported cases.

2025年1月30日 · We present four clinical cases of patients who developed autoantibodies against threonyl (PL-7) and alanyl (PL-12) synthetases associated with ASS-ILD shortly after SARS-CoV-2 infection or COVID-19 vaccination.

Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands."

Results: Anti-PL7 patients exhibited polymyositis (n=14) and dermatomyositis (n=1); extra-pulmonary manifestations of ASS included: Raynaud's phenomenon (40%), mechanic's hands (33.3%), joint impairment (26.7%), pericardial effusion (20%) and esophageal/gastrointestinal involvement (20%).

2013年10月1日 · Antisynthetase syndrome is characterized by interstitial lung disease (ILD), myositis, arthropathy, fever, Raynaud phenomenon, and mechanic’s hands. The morbidity of the syndrome is usually due to lung involvement 1.

Anti-synthetase syndrome is an autoimmune condition, characterized by antibodies directed against an aminoacycl transfer RNA synthetase along with clinical features that can include interstitial lung disease, myositis, Raynaud’s phenomenon, and arthritis.

2013年7月1日 · Anti-PL7 patients exhibited polymyositis (n = 14) and dermatomyositis (n = 1); extra-pulmonary manifestations of ASS included: Raynaud's phenomenon (40%), mechanic's hands (33.3%), joint impairment (26.7%), pericardial effusion (20%) and esophageal/gastrointestinal involvement (20%).

Anti-PL-7 antibody recognizes threonyl-tRNA-synthetases and was detected in 5-10% of IIM (1) and in 10-18% of ASS (3 - 6). Although ASS has common clinical manifestations, its relative frequency varies with the type of anti-ARS antibodies (4 - 6).

Anti-Jo-1 antibody is most common antisynthetase antibody. Others include PL-7 and PL-12. Five additional antisynthetase antibodies have been identified so far, but there are much more rare and their implications are not well understood yet. Researchers are still identifying new autoantibodies of significance to myositis diseases.

2024年6月5日 · Anti-synthetase syndrome is an idiopathic inflammatory myopathy that is characterized by inflammatory myositis, polyarthritis, interstitial lung disease, and anti-synthetase autoantibodies. It is considered a distinct entity to dermatomyositis.