2024年12月24日 · ABI1 (Abl Interactor 1) is a Protein Coding gene. Diseases associated with ABI1 include Leukemia and Spinocerebellar Ataxia, Autosomal Recessive 13. Among its related pathways are Regulation of actin dynamics for phagocytic cup …

Abi1 phosphopeptides can bind N-SH2 and C-SH2 in vitro raising the possibility of PI-3 kinase activation by competing off- and thus alleviating with the inhibitory interaction imposed by p85 subunit. WAVE complexes are the major actin nucleation-promoting factors that …

2020年6月30日 · Abi1 (Abelson interactor 1) is an adapter protein that has been implicated in nonmuscle cell migration. However, the role and mechanism of Abi1 in smooth muscle migration are largely unknown.

2024年10月1日 · Abelson interactor 1 (ABI1) is a signal-facilitating adaptor protein that regulates cytoskeleton organization and response by coordinating various protein complex interactions. It was first discovered through a yeast two-hybrid screen using the Abelson kinase (ABL1) family-specific C-terminal region as bait [1].

2025年1月4日 · Abi1 isoforms differentially regulate macropinocytosis as a consequence of their different relative affinities for activated Rac1 in Wave 2 complex. The ABI1 gene is down-regulated in gastric cancer cells. ABI1 overexpression effectively inhibits cell proliferation.

2024年6月17日 · Clinical resource with information about ABI1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2004年3月28日 · Here we use tandem mass spectrometry to identify an Abi1-based complex containing WAVE2, Nap1 (Nck-associated protein) and PIR121. Abi1 interacts directly with the WHD domain of WAVE2,...

2004年12月6日 · Binding analysis revealed that the EVH1 domain of Mena bound a polyproline structure of ABI1. Endogenous MENA and ABL1 coprecipitated with epitope-tagged ABI1 from human embryonic kidney cells. ABI1 dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA, but not of other substrates.

Description: Homo sapiens abl interactor 1 (ABI1), transcript variant 15, mRNA. (from RefSeq NM_001348031) RefSeq Summary (NM_001178123): This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin ...

Abelson interactor 1 (Abi1) is an important regulator of actin dynamics during cytoskeletal reorganization. In this study, our aim was to investigate the expression of Abi1 in colonic mucosa with and without inflammation, colonic polyps, colorectal ...