Dec 24, 2024 · ABCG2 (ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)) is a Protein Coding gene. Diseases associated with ABCG2 include Uric Acid Concentration, Serum, Quantitative Trait Locus 1 and Blood Group, Junior System .

ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source. [1] ABCG2 forms into a homodimer to assume its active transport conformation. The dimer weighs approximately 144 kDa.

The ABCG2 gene belongs to a group of genes called the ATP-binding cassette family; genes in this family provide instructions for making proteins that transport molecules across cell membranes. In the intestines, the ABCG2 protein helps …

Aug 24, 2023 · ABCG2是独一无二的，因为它参与了这两种物质的去除，这使得它能够从细胞中去除许多类型的抗癌药物，并限制了治疗效果。 实际上，它比它的家族成员拥有更多的清除工具。 研究人员开始寻找赋予ABCG2结合和去除亲水分子能力的确切残基。 在ABCG2的底物结合位点上有两种氨基酸，一种是 苏氨酸，另一种是 天冬酰胺。 这项工作强调了对抗耐药性的前进方向，特别是在癌症方面。 ABCG2抑制剂通常与化疗结合使用，但阻止ABCG2功能可能会导致脱靶的 …

ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis. Adipocyte-rich microenvironment promotes chemoresistance via upregulation of peroxisome proliferator-activated receptor gamma/ABCG2 in …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC transporters that are known to cause MDR, ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure.

Here we describe the role of ABCG2 in efflux transport and highlight its pharmacogenetic relationships. The ABCG2 gene was first discovered in 1998 in a breast cancer cell line, MCF-7/AdrVp, which was resistant to chemotherapy, but did not express other efflux transporters that had already been associated with resistance at that time [3].

Jan 8, 2024 · 1月4日，李新建团队在《细胞-代谢》（Cell Metabolism）上，在线发表了题为ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis的研究论文。该研究鉴定出ABCG2作为一种衣康酸的膜转运蛋白能够将衣康酸从胞内转运至胞外。

Jan 1, 2025 · This review aimed to illustrate the impact of ABCG2 expression and its variants on oral drug bioavailability, MDR in specific cancer cells, explore the relationship between ABCG2 expression and other disorders such as gout, Alzheimer's disease, epilepsy, and erythropoietic protoporphyria, and demonstrate the influence of various synthetic and ...

Sep 29, 2021 · With a widely distributed expression across different cell types, ABCG2 plays a central role in ATP-dependent efflux of a vast range of endogenous and exogenous molecules, thereby maintaining cellular homeostasis and providing …