2024年12月24日 · ABCG1 (ATP Binding Cassette Subfamily G Member 1) is a Protein Coding gene. Diseases associated with ABCG1 include Tangier Disease and Pulmonary Alveolar Proteinosis. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and NR1H2 and NR1H3-mediated signaling.

ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, demonstrating its direct role of ABCG1 in cellular cholesterol transport; ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles

2015年2月27日 · ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of...

The ABCG1 gene was originally identified as a homolog of the Drosophila melanogaster «white» gene, which acts as a dimeric importer of eye pigment precursors [12,13]. In humans, the ABCG1 gene is located on the long arm of chromosome 21 (21q22.3) [2,12,14,15] and consists of …

2017年2月6日 · Our findings suggest that the actin cytoskeleton plays a critical role in the plasma membrane localization of ABCG1. The ATP-binding cassette (ABC) sub-family G member 1 (ABCG1) is a...

2024年12月25日 · ABCG1 regulates pulmonary surfactant metabolism in mice and in humans. ABCG1-deficient mice have been shown to accumulate surfactant, lipid-laden macrophages and lamellar bodies of epithelial type 2 pneumocytes, B1-lymphocytes, and immunoglobulins .

In this chapter, we summarize the roles of ABCA1 and ABCG1 in maintaining cellular cholesterol homoeostasis and discuss the underlying mechanisms by which they mediate cholesterol export.

The principal substrates for at least four of the ABCG proteins are endogenous and dietary lipids, with ABCG1 implicated in particular in the export of cholesterol, and ABCG5 and G8 forming a functional heterodimer responsible for plant sterol elimination from the body.

Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL.

2022年1月25日 · The cryo-EM structure of human ABCG1 reported by Xu et al. reveals an ABCG1-driven cholesterol transport cycle initiated by sphingomyelin-assisted cholesterol recruitment and accomplished with cholesterol sequestration by the acceptors.