ABCC1 plays a role in the multidrug resistance of cancerous tumor cells due to its ability to transport many chemotherapeutic drugs out of the cells. The ABCC1 transporter protein is especially prevalent in neuroblastoma and cancer cells found in the lung, breast and prostate.

2024年12月24日 · ABCC1 (ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)) is a Protein Coding gene. Diseases associated with ABCC1 include Deafness, Autosomal Dominant 77 and Rare Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Nuclear events mediated by NFE2L2 and Fatty acid metabolism.

ABCC1 modulates negative feedback control of the hypothalamic-pituitary-adrenal axis in vivo in humans. Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.

2023年9月19日 · ATP-binding cassette (ABC) transporters mediate chemotherapy resistance but their role in modulating the activity of targeted small-molecule inhibitors is unclear. Using CRISPR/Cas9 screening, we...

由该基因编码的蛋白质是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。 这种完整的转运蛋白是参与多重耐药性的 MRP 亚家族的成员。 这种蛋白质作为多特异性有机阴离子转运蛋白发挥作用，以氧化型谷胱甘肽、半胱氨酰白三烯和活化的黄曲霉毒素 B1 作为底物。 这种蛋白质还转运类固醇激素和胆汁盐的葡糖苷酸和硫酸结合物。 …

2024年12月24日 · 这项研究成功揭示了ABCC1作为关键外排泵，持续限制多种癌细胞对PROTAC的敏感性，为理解PROTAC在癌细胞中的转运机制和耐药问题提供了重要依据。 尽管目前尚未明确PROTAC的导入机制，但该研究为后续探索如何优化PROTAC结构、克服耐药性指明了方向，有望推动PROTAC在临床治疗中的广泛应用，为癌症治疗带来新的突破。 参考文献： Wolf G, Craigon C, Teoh ST, et al. The efflux pump ABCC1/MRP1 constitutively restricts PROTAC …

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells.

2025年1月10日 · 近期在人类和小鼠细胞中的研究已发现ATP结合盒（ABC）C亚家族成员1（ABCC1）是一个直接的ATP依赖性cGAMP外排泵。 这些研究还表明，细胞内源性的STING反应受限于ABCC1介导的cGAMP外排。 外排的cGAMP可以通过SLC19A1和SLC46A2等进口蛋白被旁观细胞吸收，导致未感染细胞中STING信号通路的激活。 近期关于SLC19A1与cGAMP复合物的结构研究提供了cGAMP进入细胞机制的见解。 然而，ABCC1介导的cGAMP外排机制仍未完 …

2025年1月14日 · ABCC1 (also known as multidrug-resistant protein 1 [MRP1]) actively pumps a variety of anti-cancer drugs out of the malignant cells using the energy from ATP. 31 In addition to the export of xenobiotics, ABCC1 also exports several physiologically important molecules, including leukotriene C4 (LTC 4), estrogens, prostaglandins, and glutathione ...

ABCC1. ABCC1, also known as multidrug resistance protein 1 (MRP1), is an ABC transporter which has been widely studied in the context of pharmacogenetics and cancer . The ABCC1 gene maps to 16p13.1, and is expressed on the basolateral membrane of epithelial cells in most tissues .