2024年1月1日 · Adeno-associated virus (AAV) is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest. Among the AAV vectors, AAV serotype 8 (AAV8) has attracted much attention for its efficient and …

腺相关病毒（Adeno-associated virus，AAV）是目前发现结构最简单的、无包膜的单链DNA病毒，病毒基因组长约有4.7Kb，属于细小病毒家族。AAV自身不能复制，必须依赖于其它病毒复制，比如腺病毒、疱疹病毒、杆状病毒，有超过80%的人携带AAV，未发现AAV与任何疾病相关。

2017年2月9日 · AAV serotype 8 (AAV8) in particular has been demonstrated to be one of the most effective vectors in some structures of the CNS, producing the highest rate of transgene transduction in the striatum compared with other serotypes, in the absence of neurotoxicity (Aschauer et al., 2013).

AAV serotype 8 (AAV8) shows a significantly greater liver transduction efficiency than those of other serotypes, which has resulted in efforts to develop this virus as a gene therapy vector for hemophilia A and familial hypercholesterolemia.

aav8是众多aav血清型中的一种，它特别适合于靶向肝脏细胞，因此在用于治疗肝脏疾病的基因治疗中显示出极大的潜能。 除此之外，AAV8也能有效感染其它多种组织，包括心脏、骨骼肌和不同的中枢神经系统区域。

Adeno-associated viruses (AAVs) are being developed as gene therapy vectors, and their efficacy could be improved by a detailed understanding of their viral capsid structures. AAV serotype 8 (AAV8) shows a significantly greater liver transduction ...

2023年3月24日 · Adeno-associated virus (AAV) is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of interest. Among the AAV vectors, AAV serotype 8 (AAV8) has attracted much attention for its …

AAV serotype 8 (AAV8) in particular has been demonstrated to be one of the most effective vectors in some structures of the CNS, producing the highest rate of transgene transduction in the striatum compared with other serotypes, in the absence of neurotoxicity (Aschauer et al., 2013).

2018年9月14日 · Injection of AAV serotype 8 (AAV8) vector carrying the GNMT gene (AAV8-GNMT) in Gnmt−/− mice increased GNMT expression and downregulated pro-inflammatory responses, resulting in reduced...

2007年6月14日 · AAV serotype 8 (AAV8) shows a significantly greater liver transduction efficiency than those of other serotypes, which has resulted in efforts to develop this virus as a gene therapy vector for hemophilia A and familial hypercholesterolemia.