The A2780 human ovarian cancer cell line was established from tumour tissue from an untreated patient. Cells grow as a monolayer and in suspension in spinner cultures. A2780 is the parent line to the cisplatin resistant cell line A2780 cis (Sigma catalogue no. 93112517) and the adriamycin resistant cell line A2780 ADR (Sigma catalogue no ...

Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis.

2019年4月2日 · A2780 cells formed a thick proliferative cell layer on top of the collagen and invaded in small clumps of cells. This cluster invasion phenotype is characteristic of epithelial tumour...

2015年6月17日 · Two of the SOC cell lines we examined—SKOV3 and A2780—account for nearly 60% of ovarian carcinoma-related publications according to a recent report 13, and just 5 SOC lines account for nearly...

Access high quality human ovarian adenocarcinoma A2780 cells from CancerTools.org for cisplatin resistance, transfection, apoptosis, cancer research.

We have characterized 39 ovarian cancer cell lines under uniform conditions for growth characteristics, mRNA/microRNA expression, exon sequencing, drug response for clinically-relevant therapeutics and collated all available information on the original clinical features and site of …

Ovarian cancer A2780 cell line is used as a model system that represents endometrioid carcinomas, a special pathological type of epithelial ovarian cancer.

Examples of these cell lines are A2780 ovarian cancer cells and the human mammary carcinoma cell line MCF-7. In the former, cell detachment of the cells can be prevented if the plates are centrifuged prior to medium substitution.

The present study assessed the expression of ALDH1 in human ovarian cancer cells: Wild-type A2780/WT cells and the related paclitaxel-resistant A2780/PTX cell line. The colony formation assay was used to characterize differences accompanied by ALDH1 expression.

A2780 is the parent line to the cisplatin resistant cell line A2780 cis (catalogue no. 152708) and the adriamycin resistant cell line A2780 ADR (catalogue no. 152707). This cell line has been used in a variety of research, including understanding the role of Snail and Slug in ovarian tumour neovascularization; how to overcome cisplatin ...

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2023年6月25日 · Here, we performed a detailed analysis of drug-sensitive ovarian cancer cell lines (A2780 and W1) and the influence of ovarian CAFs on the A2780 and W1 cells morphology, genes and proteins expression.

Collateral susceptibility of adriamycin-, melphalan- and cisplatin-resistant human ovarian tumor cells to bleomycin. Characterization of a cis-diamminedichloroplatinum (II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.

2014年12月15日 · Here we find that volume-sensitive taurine release in cisplatin-sensitive [wild-type (WT)] human ovarian cancer A2780 cells is reduced in the presence of the phospholipase A2 inhibitor bromenol lactone, the 5-lipoxygenase (5-LO) inhibitor ETH 615-139, and the cysteine leukotriene receptor 1 (CysLT1) antagonist zafirlukast and impaired by the ...

2022年9月26日 · Inhibition of PI3K activity blocks colony formation in A2780/PTX cells. (A) Representative images and (B) summary data showing the effect of the PI3K inhibitor, LY294002 (10 μM). Images of the cells were captured after 14 days (upper panels in A).

We studied two human ovarian carcinoma cell lines for cisplatin resistance, which differed with respect to ERCC1. The A2780/CP70 cell line has been extensively studied previously, and has the wild-type ERCC1 sequence.

CBDCA-resistant A2780 ovarian cancer cells is a reliable model of CBDCA resistance that shows several DEGs involved in molecular functions such as transmembrane activity, protein binding to cell surface receptor and catalytic activity.

2023年6月25日 · Methods: Here, we performed a detailed analysis of drug-sensitive ovarian cancer cell lines (A2780 and W1) and the influence of ovarian CAFs on the A2780 and W1 cells morphology, genes and proteins expression.

Using the paclitaxel-resistant A2780/PTX cell line, it was demonstrated that high aldehyde dehydrogenase 1 (ALDH1) activity identifies CSCs from diverse sources. Furthermore, the A2780/PTX cells had a strong ability to form colonies in soft agar assays.

2019年3月21日 · CBDCA-resistant A2780 ovarian cancer cells is a reliable model of CBDCA resistance that shows several DEGs involved in molecular functions such as transmembrane activity, protein binding to cell surface receptor and catalytic activity.